A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

The primary cilium organizes Hedgehog signaling and shapes embryonic development, and its dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic screen for Hedgehog signaling by engineering antibiotic-based selection of Hedgehog-responsive cells and applying genome-wi...

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Detalles Bibliográficos
Autores principales: Breslow, David K., Hoogendoorn, Sascha, Kopp, Adam R., Morgens, David W., Vu, Brandon K., Kennedy, Margaret C., Han, Kyuho, Li, Amy, Hess, Gaelen T., Bassik, Michael C., Chen, James K., Nachury, Maxence V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862771/
https://www.ncbi.nlm.nih.gov/pubmed/29459677
http://dx.doi.org/10.1038/s41588-018-0054-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862771/
https://www.ncbi.nlm.nih.gov/pubmed/29459677
http://dx.doi.org/10.1038/s41588-018-0054-7

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