Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing

The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11, or STXBP2 leads to a potentially fatal im...

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Detalles Bibliográficos
Autores principales: Lopez, Jamie A., Noori, Tahereh, Minson, Adrian, Li Jovanoska, Lu, Thia, Kevin, Hildebrand, Michael S., Akhlaghi, Hedieh, Darcy, Phillip K., Kershaw, Michael H., Brown, Natasha J., Grigg, Andrew, Trapani, Joseph A., Voskoboinik, Ilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862791/
https://www.ncbi.nlm.nih.gov/pubmed/29599780
http://dx.doi.org/10.3389/fimmu.2018.00529

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