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CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides

NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress other immunocompetent cells through an immediate production of a...

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Autores principales: Nishioka, Yusuke, Masuda, Sakiko, Tomaru, Utano, Ishizu, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862807/
https://www.ncbi.nlm.nih.gov/pubmed/29599785
http://dx.doi.org/10.3389/fimmu.2018.00548
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author Nishioka, Yusuke
Masuda, Sakiko
Tomaru, Utano
Ishizu, Akihiro
author_facet Nishioka, Yusuke
Masuda, Sakiko
Tomaru, Utano
Ishizu, Akihiro
author_sort Nishioka, Yusuke
collection PubMed
description NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress other immunocompetent cells through an immediate production of a large amount of cytokines, they are regarded as immunological modulators. CD1d-restricted NKT cells are classified into two subsets, namely, type I and type II. CD1d-restricted type I NKT cells express invariant T cell receptors (TCRs) and react with lipid antigens, including the marine sponge-derived glycolipid α-galactosylceramide. On the contrary, CD1d-restricted type II NKT cells recognize a wide variety of antigens, including glycolipids, phospholipids, and hydrophobic peptides, by their diverse TCRs. In this review, we focus particularly on CD1d-restricted type II NKT cells that recognize endogenous hydrophobic peptides presented by CD1d. Previous studies have demonstrated that CD1d-restricted type I NKT cells usually act as pro-inflammatory cells but sometimes behave as anti-inflammatory cells. It has been also demonstrated that CD1d-restricted type II NKT cells play opposite roles to CD1d-restricted type I NKT cells; thus, they function as anti-inflammatory or pro-inflammatory cells depending on the situation. In line with this, CD1d-restricted type II NKT cells that recognize type II collagen peptide have been demonstrated to act as anti-inflammatory cells in diverse inflammation-induction models in mice, whereas pro-inflammatory CD1d-restricted type II NKT cells reactive with sterol carrier protein 2 peptide have been demonstrated to be involved in the development of small vessel vasculitis in rats.
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spelling pubmed-58628072018-03-29 CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides Nishioka, Yusuke Masuda, Sakiko Tomaru, Utano Ishizu, Akihiro Front Immunol Immunology NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress other immunocompetent cells through an immediate production of a large amount of cytokines, they are regarded as immunological modulators. CD1d-restricted NKT cells are classified into two subsets, namely, type I and type II. CD1d-restricted type I NKT cells express invariant T cell receptors (TCRs) and react with lipid antigens, including the marine sponge-derived glycolipid α-galactosylceramide. On the contrary, CD1d-restricted type II NKT cells recognize a wide variety of antigens, including glycolipids, phospholipids, and hydrophobic peptides, by their diverse TCRs. In this review, we focus particularly on CD1d-restricted type II NKT cells that recognize endogenous hydrophobic peptides presented by CD1d. Previous studies have demonstrated that CD1d-restricted type I NKT cells usually act as pro-inflammatory cells but sometimes behave as anti-inflammatory cells. It has been also demonstrated that CD1d-restricted type II NKT cells play opposite roles to CD1d-restricted type I NKT cells; thus, they function as anti-inflammatory or pro-inflammatory cells depending on the situation. In line with this, CD1d-restricted type II NKT cells that recognize type II collagen peptide have been demonstrated to act as anti-inflammatory cells in diverse inflammation-induction models in mice, whereas pro-inflammatory CD1d-restricted type II NKT cells reactive with sterol carrier protein 2 peptide have been demonstrated to be involved in the development of small vessel vasculitis in rats. Frontiers Media S.A. 2018-03-15 /pmc/articles/PMC5862807/ /pubmed/29599785 http://dx.doi.org/10.3389/fimmu.2018.00548 Text en Copyright © 2018 Nishioka, Masuda, Tomaru and Ishizu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Nishioka, Yusuke
Masuda, Sakiko
Tomaru, Utano
Ishizu, Akihiro
CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title_full CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title_fullStr CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title_full_unstemmed CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title_short CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
title_sort cd1d-restricted type ii nkt cells reactive with endogenous hydrophobic peptides
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862807/
https://www.ncbi.nlm.nih.gov/pubmed/29599785
http://dx.doi.org/10.3389/fimmu.2018.00548
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