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The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters
The authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (DAT) and extrastriatal serotonin transporter (SERT) by (123)I-FP-CIT single-photon emission computed tomography. The study population consisted of 192 healthy controls with scree...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862836/ https://www.ncbi.nlm.nih.gov/pubmed/29563547 http://dx.doi.org/10.1038/s41598-018-22814-8 |
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author | Nam, Su Bong Kim, Keunyoung Kim, Bum Soo Im, Hyung-Jun Lee, Seung Hun Kim, Seong-Jang Kim, In Joo Pak, Kyoungjune |
author_facet | Nam, Su Bong Kim, Keunyoung Kim, Bum Soo Im, Hyung-Jun Lee, Seung Hun Kim, Seong-Jang Kim, In Joo Pak, Kyoungjune |
author_sort | Nam, Su Bong |
collection | PubMed |
description | The authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (DAT) and extrastriatal serotonin transporter (SERT) by (123)I-FP-CIT single-photon emission computed tomography. The study population consisted of 192 healthy controls with screening (123)I-FP-CIT scans. Specific bindings of (123)I-FP-CIT to DAT and SERT were calculated using regions of interest. Specific binding ratios (SBRs) of DAT and SERT except pons (r = 0.2217, p = 0.0026), were not correlated with body mass index (BMI). SBRs of midbrains correlated negatively with the BMIs of obese subjects (r = −0.3126, p = 0.0496), and positively with the those of non-obese subjects (r = 0.2327, p = 0.0053). SBRs of caudate nucleus (r = −0.3175, p < 0.0001), striatum (r = −0.226, p = 0.0022), and thalamus (r = −0.1978, p = 0.0074) reduced with age, and SERT availability was higher in males. However, DAT availability was similar in males and females. In conclusion, obesity has an effect on midbrain SERT availability. In addition, BMI was correlated with pontine SERT availability but not with striatal DAT availability. SERT availability was higher in males, but DAT availability showed no gender predilection. |
format | Online Article Text |
id | pubmed-5862836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58628362018-03-27 The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters Nam, Su Bong Kim, Keunyoung Kim, Bum Soo Im, Hyung-Jun Lee, Seung Hun Kim, Seong-Jang Kim, In Joo Pak, Kyoungjune Sci Rep Article The authors investigated relations between obesity, age, and sex and the availabilities of striatal dopamine transporter (DAT) and extrastriatal serotonin transporter (SERT) by (123)I-FP-CIT single-photon emission computed tomography. The study population consisted of 192 healthy controls with screening (123)I-FP-CIT scans. Specific bindings of (123)I-FP-CIT to DAT and SERT were calculated using regions of interest. Specific binding ratios (SBRs) of DAT and SERT except pons (r = 0.2217, p = 0.0026), were not correlated with body mass index (BMI). SBRs of midbrains correlated negatively with the BMIs of obese subjects (r = −0.3126, p = 0.0496), and positively with the those of non-obese subjects (r = 0.2327, p = 0.0053). SBRs of caudate nucleus (r = −0.3175, p < 0.0001), striatum (r = −0.226, p = 0.0022), and thalamus (r = −0.1978, p = 0.0074) reduced with age, and SERT availability was higher in males. However, DAT availability was similar in males and females. In conclusion, obesity has an effect on midbrain SERT availability. In addition, BMI was correlated with pontine SERT availability but not with striatal DAT availability. SERT availability was higher in males, but DAT availability showed no gender predilection. Nature Publishing Group UK 2018-03-21 /pmc/articles/PMC5862836/ /pubmed/29563547 http://dx.doi.org/10.1038/s41598-018-22814-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nam, Su Bong Kim, Keunyoung Kim, Bum Soo Im, Hyung-Jun Lee, Seung Hun Kim, Seong-Jang Kim, In Joo Pak, Kyoungjune The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title | The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title_full | The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title_fullStr | The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title_full_unstemmed | The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title_short | The Effect of Obesity on the Availabilities of Dopamine and Serotonin Transporters |
title_sort | effect of obesity on the availabilities of dopamine and serotonin transporters |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862836/ https://www.ncbi.nlm.nih.gov/pubmed/29563547 http://dx.doi.org/10.1038/s41598-018-22814-8 |
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