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Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is esse...

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Autores principales: Fejzo, Marlena S., Sazonova, Olga V., Sathirapongsasuti, J. Fah, Hallgrímsdóttir, Ingileif B., Vacic, Vladimir, MacGibbon, Kimber W., Schoenberg, Frederic P., Mancuso, Nicholas, Slamon, Dennis J., Mullin, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862842/
https://www.ncbi.nlm.nih.gov/pubmed/29563502
http://dx.doi.org/10.1038/s41467-018-03258-0
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author Fejzo, Marlena S.
Sazonova, Olga V.
Sathirapongsasuti, J. Fah
Hallgrímsdóttir, Ingileif B.
Vacic, Vladimir
MacGibbon, Kimber W.
Schoenberg, Frederic P.
Mancuso, Nicholas
Slamon, Dennis J.
Mullin, Patrick M.
author_facet Fejzo, Marlena S.
Sazonova, Olga V.
Sathirapongsasuti, J. Fah
Hallgrímsdóttir, Ingileif B.
Vacic, Vladimir
MacGibbon, Kimber W.
Schoenberg, Frederic P.
Mancuso, Nicholas
Slamon, Dennis J.
Mullin, Patrick M.
author_sort Fejzo, Marlena S.
collection PubMed
description Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p < 5 × 10(−8)) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease.
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spelling pubmed-58628422018-03-23 Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Fejzo, Marlena S. Sazonova, Olga V. Sathirapongsasuti, J. Fah Hallgrímsdóttir, Ingileif B. Vacic, Vladimir MacGibbon, Kimber W. Schoenberg, Frederic P. Mancuso, Nicholas Slamon, Dennis J. Mullin, Patrick M. Nat Commun Article Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3–2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p < 5 × 10(−8)) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease. Nature Publishing Group UK 2018-03-21 /pmc/articles/PMC5862842/ /pubmed/29563502 http://dx.doi.org/10.1038/s41467-018-03258-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fejzo, Marlena S.
Sazonova, Olga V.
Sathirapongsasuti, J. Fah
Hallgrímsdóttir, Ingileif B.
Vacic, Vladimir
MacGibbon, Kimber W.
Schoenberg, Frederic P.
Mancuso, Nicholas
Slamon, Dennis J.
Mullin, Patrick M.
Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title_full Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title_fullStr Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title_full_unstemmed Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title_short Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
title_sort placenta and appetite genes gdf15 and igfbp7 are associated with hyperemesis gravidarum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862842/
https://www.ncbi.nlm.nih.gov/pubmed/29563502
http://dx.doi.org/10.1038/s41467-018-03258-0
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