A multiple myeloma-specific capture sequencing platform discovers novel translocations and frequent, risk-associated point mutations in IGLL5

Multiple myeloma (MM) is a disease of copy number variants (CNVs), chromosomal translocations, and single-nucleotide variants (SNVs). To enable integrative studies across these diverse mutation types, we developed a capture-based sequencing platform to detect their occurrence in 465 genes altered in...

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Detalles Bibliográficos
Autores principales: White, Brian S., Lanc, Irena, O’Neal, Julie, Gupta, Harshath, Fulton, Robert S., Schmidt, Heather, Fronick, Catrina, Belter, Edward A., Fiala, Mark, King, Justin, Ahmann, Greg J., DeRome, Mary, Mardis, Elaine R., Vij, Ravi, DiPersio, John F., Levy, Joan, Auclair, Daniel, Tomasson, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862875/
https://www.ncbi.nlm.nih.gov/pubmed/29563506
http://dx.doi.org/10.1038/s41408-018-0062-y

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