RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

The roles of RNA 5-methylcytosine (RNA:m(5)C) and RNA:m(5)C methyltransferases (RCMTs) in lineage-associated chromatin organization and drug response/resistance are unclear. Here we demonstrate that the RCMTs, namely NSUN3 and DNMT2, directly bind hnRNPK, a conserved RNA-binding protein. hnRNPK inte...

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Detalles Bibliográficos
Autores principales: Cheng, Jason X., Chen, Li, Li, Yuan, Cloe, Adam, Yue, Ming, Wei, Jiangbo, Watanabe, Kenneth A., Shammo, Jamile M., Anastasi, John, Shen, Qingxi J., Larson, Richard A., He, Chuan, Le Beau, Michelle M., Vardiman, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862959/
https://www.ncbi.nlm.nih.gov/pubmed/29563491
http://dx.doi.org/10.1038/s41467-018-03513-4

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