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Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma

BACKGROUND: Clear cell sarcoma is a rare malignant soft tissue neoplasm that typically involves tendons and aponeurosis. Clear cell sarcoma in the dermis is an extremely rare occurrence, and it is difficult to differentiate between this neoplasm and dermal malignant melanoma because they have simila...

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Autores principales: Obiorah, Ifeyinwa E., Brenholz, Pauline, Özdemirli, Metin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863262/
https://www.ncbi.nlm.nih.gov/pubmed/29072181
http://dx.doi.org/10.4274/balkanmedj.2017.0796
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author Obiorah, Ifeyinwa E.
Brenholz, Pauline
Özdemirli, Metin
author_facet Obiorah, Ifeyinwa E.
Brenholz, Pauline
Özdemirli, Metin
author_sort Obiorah, Ifeyinwa E.
collection PubMed
description BACKGROUND: Clear cell sarcoma is a rare malignant soft tissue neoplasm that typically involves tendons and aponeurosis. Clear cell sarcoma in the dermis is an extremely rare occurrence, and it is difficult to differentiate between this neoplasm and dermal malignant melanoma because they have similar morphologic and immunohistochemical features. Although rare, clear cell sarcoma of the skin typically occurs in the extremities. To our knowledge, there are no reported cases of primary clear cell sarcoma of the skin occurring in the neck. Here, we report an unusual case of clear cell sarcoma arising in the skin of the neck. CASE REPORT: A 43-year-old female presented with a right neck lesion. Histologic sections of the lesion showed a nodular proliferation of spindle cells with pale cytoplasm with epithelioid features involving the entire dermis with no epidermal component. The tumour cells were positive for melanocytic markers, including S100 and Human Melanoma Black 45, which led to an initial diagnosis of malignant melanoma. Fluorescence in situ hybridization showed a rearrangement of the EWSR1 gene on chromosome 22q12, which led to a diagnosis of primary clear cell sarcoma in the skin. CONCLUSION: Because the treatments for clear cell sarcoma and conventional melanoma are different, fluorescence in situ hybridization for EWSR1 should be performed in any dermal lesions with melanocytic features that do not have an in situ component.
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spelling pubmed-58632622018-04-23 Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma Obiorah, Ifeyinwa E. Brenholz, Pauline Özdemirli, Metin Balkan Med J Case Report BACKGROUND: Clear cell sarcoma is a rare malignant soft tissue neoplasm that typically involves tendons and aponeurosis. Clear cell sarcoma in the dermis is an extremely rare occurrence, and it is difficult to differentiate between this neoplasm and dermal malignant melanoma because they have similar morphologic and immunohistochemical features. Although rare, clear cell sarcoma of the skin typically occurs in the extremities. To our knowledge, there are no reported cases of primary clear cell sarcoma of the skin occurring in the neck. Here, we report an unusual case of clear cell sarcoma arising in the skin of the neck. CASE REPORT: A 43-year-old female presented with a right neck lesion. Histologic sections of the lesion showed a nodular proliferation of spindle cells with pale cytoplasm with epithelioid features involving the entire dermis with no epidermal component. The tumour cells were positive for melanocytic markers, including S100 and Human Melanoma Black 45, which led to an initial diagnosis of malignant melanoma. Fluorescence in situ hybridization showed a rearrangement of the EWSR1 gene on chromosome 22q12, which led to a diagnosis of primary clear cell sarcoma in the skin. CONCLUSION: Because the treatments for clear cell sarcoma and conventional melanoma are different, fluorescence in situ hybridization for EWSR1 should be performed in any dermal lesions with melanocytic features that do not have an in situ component. Galenos Publishing 2018-03 2018-03-15 /pmc/articles/PMC5863262/ /pubmed/29072181 http://dx.doi.org/10.4274/balkanmedj.2017.0796 Text en © Copyright 2018, Trakya University Faculty of Medicine http://creativecommons.org/licenses/by/2.5/ Balkan Medical Journal
spellingShingle Case Report
Obiorah, Ifeyinwa E.
Brenholz, Pauline
Özdemirli, Metin
Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title_full Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title_fullStr Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title_full_unstemmed Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title_short Primary Clear Cell Sarcoma of the Dermis Mimicking Malignant Melanoma
title_sort primary clear cell sarcoma of the dermis mimicking malignant melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863262/
https://www.ncbi.nlm.nih.gov/pubmed/29072181
http://dx.doi.org/10.4274/balkanmedj.2017.0796
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