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MicroRNA and Microvascular Complications of Diabetes

In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of...

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Detalles Bibliográficos
Autores principales: Barutta, F., Bellini, S., Mastrocola, R., Bruno, G., Gruden, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863305/
https://www.ncbi.nlm.nih.gov/pubmed/29707000
http://dx.doi.org/10.1155/2018/6890501
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author Barutta, F.
Bellini, S.
Mastrocola, R.
Bruno, G.
Gruden, G.
author_facet Barutta, F.
Bellini, S.
Mastrocola, R.
Bruno, G.
Gruden, G.
author_sort Barutta, F.
collection PubMed
description In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications.
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spelling pubmed-58633052018-04-29 MicroRNA and Microvascular Complications of Diabetes Barutta, F. Bellini, S. Mastrocola, R. Bruno, G. Gruden, G. Int J Endocrinol Review Article In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications. Hindawi 2018-03-07 /pmc/articles/PMC5863305/ /pubmed/29707000 http://dx.doi.org/10.1155/2018/6890501 Text en Copyright © 2018 F. Barutta et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Barutta, F.
Bellini, S.
Mastrocola, R.
Bruno, G.
Gruden, G.
MicroRNA and Microvascular Complications of Diabetes
title MicroRNA and Microvascular Complications of Diabetes
title_full MicroRNA and Microvascular Complications of Diabetes
title_fullStr MicroRNA and Microvascular Complications of Diabetes
title_full_unstemmed MicroRNA and Microvascular Complications of Diabetes
title_short MicroRNA and Microvascular Complications of Diabetes
title_sort microrna and microvascular complications of diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863305/
https://www.ncbi.nlm.nih.gov/pubmed/29707000
http://dx.doi.org/10.1155/2018/6890501
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