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MicroRNA and Microvascular Complications of Diabetes
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863305/ https://www.ncbi.nlm.nih.gov/pubmed/29707000 http://dx.doi.org/10.1155/2018/6890501 |
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author | Barutta, F. Bellini, S. Mastrocola, R. Bruno, G. Gruden, G. |
author_facet | Barutta, F. Bellini, S. Mastrocola, R. Bruno, G. Gruden, G. |
author_sort | Barutta, F. |
collection | PubMed |
description | In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications. |
format | Online Article Text |
id | pubmed-5863305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58633052018-04-29 MicroRNA and Microvascular Complications of Diabetes Barutta, F. Bellini, S. Mastrocola, R. Bruno, G. Gruden, G. Int J Endocrinol Review Article In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications. Hindawi 2018-03-07 /pmc/articles/PMC5863305/ /pubmed/29707000 http://dx.doi.org/10.1155/2018/6890501 Text en Copyright © 2018 F. Barutta et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Barutta, F. Bellini, S. Mastrocola, R. Bruno, G. Gruden, G. MicroRNA and Microvascular Complications of Diabetes |
title | MicroRNA and Microvascular Complications of Diabetes |
title_full | MicroRNA and Microvascular Complications of Diabetes |
title_fullStr | MicroRNA and Microvascular Complications of Diabetes |
title_full_unstemmed | MicroRNA and Microvascular Complications of Diabetes |
title_short | MicroRNA and Microvascular Complications of Diabetes |
title_sort | microrna and microvascular complications of diabetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863305/ https://www.ncbi.nlm.nih.gov/pubmed/29707000 http://dx.doi.org/10.1155/2018/6890501 |
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