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Mast Cells and Nerve Signal Conduction in Acupuncture
Nerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) interve...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863328/ https://www.ncbi.nlm.nih.gov/pubmed/29707031 http://dx.doi.org/10.1155/2018/3524279 |
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author | Yin, Na Yang, Hongwei Yao, Wei Xia, Ying Ding, Guanghong |
author_facet | Yin, Na Yang, Hongwei Yao, Wei Xia, Ying Ding, Guanghong |
author_sort | Yin, Na |
collection | PubMed |
description | Nerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) intervention in anesthetized Sprague-Dawley (SD) rats. We used single unit nerve recording techniques to collect nerve signals from DRP afferent nerves for a 45-minute period that includes 4 stages, that is, base, drug absorption, acupuncture, and recovery stages. We analyzed the recorded signals from time-domain and frequency-domain perspectives. The results showed that once acupuncture needle was inserted, twisting needle excited more nerves discharges than those at base discharges in ACU (from 35.1 ± 7.2 to 47 ± 9.2 Hz, P = 0.004), and there existed the same trend in Saline + ACU group (from 23.8 ± 2.6 to 29.8 ± 4.2 Hz, P = 0.059). There was no change of nerve discharges under twisting needle with injection of DSCG (from 34.8 ± 5.3 to 34.7 ± 4.4 Hz, P = 0.480). We conclude that acupuncture manipulation promotes neural signal production and DSCG could partly inhibit nerve discharges. |
format | Online Article Text |
id | pubmed-5863328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58633282018-04-29 Mast Cells and Nerve Signal Conduction in Acupuncture Yin, Na Yang, Hongwei Yao, Wei Xia, Ying Ding, Guanghong Evid Based Complement Alternat Med Research Article Nerve and mast cells are densely distributed around acupoints in connective tissue. To explore the internal relations between them in acupuncture effect, we examined dorsal root potential (DRP) response to acupuncture at Zusanli (ST36) under sodium cromoglicate (DSCG, a mast cell stabilizer) intervention in anesthetized Sprague-Dawley (SD) rats. We used single unit nerve recording techniques to collect nerve signals from DRP afferent nerves for a 45-minute period that includes 4 stages, that is, base, drug absorption, acupuncture, and recovery stages. We analyzed the recorded signals from time-domain and frequency-domain perspectives. The results showed that once acupuncture needle was inserted, twisting needle excited more nerves discharges than those at base discharges in ACU (from 35.1 ± 7.2 to 47 ± 9.2 Hz, P = 0.004), and there existed the same trend in Saline + ACU group (from 23.8 ± 2.6 to 29.8 ± 4.2 Hz, P = 0.059). There was no change of nerve discharges under twisting needle with injection of DSCG (from 34.8 ± 5.3 to 34.7 ± 4.4 Hz, P = 0.480). We conclude that acupuncture manipulation promotes neural signal production and DSCG could partly inhibit nerve discharges. Hindawi 2018-03-07 /pmc/articles/PMC5863328/ /pubmed/29707031 http://dx.doi.org/10.1155/2018/3524279 Text en Copyright © 2018 Na Yin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yin, Na Yang, Hongwei Yao, Wei Xia, Ying Ding, Guanghong Mast Cells and Nerve Signal Conduction in Acupuncture |
title | Mast Cells and Nerve Signal Conduction in Acupuncture |
title_full | Mast Cells and Nerve Signal Conduction in Acupuncture |
title_fullStr | Mast Cells and Nerve Signal Conduction in Acupuncture |
title_full_unstemmed | Mast Cells and Nerve Signal Conduction in Acupuncture |
title_short | Mast Cells and Nerve Signal Conduction in Acupuncture |
title_sort | mast cells and nerve signal conduction in acupuncture |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863328/ https://www.ncbi.nlm.nih.gov/pubmed/29707031 http://dx.doi.org/10.1155/2018/3524279 |
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