MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review

Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease-specific myocardial structural, functional and metabolic changes. This review will focus on the contemporar...

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Autores principales: Levelt, Eylem, Gulsin, Gaurav, Neubauer, Stefan, McCann, Gerry P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863473/
https://www.ncbi.nlm.nih.gov/pubmed/29440374
http://dx.doi.org/10.1530/EJE-17-0724
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author Levelt, Eylem
Gulsin, Gaurav
Neubauer, Stefan
McCann, Gerry P
author_facet Levelt, Eylem
Gulsin, Gaurav
Neubauer, Stefan
McCann, Gerry P
author_sort Levelt, Eylem
collection PubMed
description Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease-specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies and cardiovascular outcomes with new classes of glucose-lowering therapies.
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spelling pubmed-58634732018-03-23 MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review Levelt, Eylem Gulsin, Gaurav Neubauer, Stefan McCann, Gerry P Eur J Endocrinol Review Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes contributes to the development of heart failure through a variety of mechanisms, including disease-specific myocardial structural, functional and metabolic changes. This review will focus on the contemporary contributions of state of the art non-invasive technologies to our understanding of diabetic cardiomyopathy, including data on cardiac disease phenotype, cardiac energy metabolism and energetic deficiency, ectopic and visceral adiposity, diabetic liver disease, metabolic modulation strategies and cardiovascular outcomes with new classes of glucose-lowering therapies. Bioscientifica Ltd 2018-02-12 /pmc/articles/PMC5863473/ /pubmed/29440374 http://dx.doi.org/10.1530/EJE-17-0724 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Levelt, Eylem
Gulsin, Gaurav
Neubauer, Stefan
McCann, Gerry P
MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title_full MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title_fullStr MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title_full_unstemmed MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title_short MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
title_sort mechanisms in endocrinology: diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863473/
https://www.ncbi.nlm.nih.gov/pubmed/29440374
http://dx.doi.org/10.1530/EJE-17-0724
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