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Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications

BACKGROUND: Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectively neoantigens, may promote T1D. These findings have given more credence to th...

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Detalles Bibliográficos
Autores principales:	Sidney, John, Vela, Jose Luis, Friedrich, Dave, Kolla, Ravi, von Herrath, Matthias, Wesley, Johnna D., Sette, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863483/ https://www.ncbi.nlm.nih.gov/pubmed/29562882 http://dx.doi.org/10.1186/s12865-018-0250-3

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