Cargando…

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications

BACKGROUND: Type 1 diabetes (T1D) is thought to be an autoimmune disease driven by anti-islet antigen responses and mediated by T-cells. Recent published data suggests that T-cell reactivity to modified peptides, effectively neoantigens, may promote T1D. These findings have given more credence to th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sidney, John, Vela, Jose Luis, Friedrich, Dave, Kolla, Ravi, von Herrath, Matthias, Wesley, Johnna D., Sette, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863483/ https://www.ncbi.nlm.nih.gov/pubmed/29562882 http://dx.doi.org/10.1186/s12865-018-0250-3

Ejemplares similares

Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes
por: Wesley, Johnna D, et al.
Publicado: (2021)

Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)
por: Vaughan, Kerrie, et al.
Publicado: (2013)

Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes
por: Paul, Sinu, et al.
Publicado: (2017)

HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8(+) T Cells in Chronic Chagas Disease
por: Alvarez, María G., et al.
Publicado: (2008)

Characterizing monkeypox virus specific CD8+ T cell epitopes in rhesus macaques
por: Song, Haifeng, et al.
Publicado: (2013)

Evaluating the Immunogenicity of Protein Drugs by Applying In Vitro MHC Binding Data and the Immune Epitope Database and Analysis Resource
por: Paul, Sinu, et al.
Publicado: (2013)

Immunodominant Tuberculosis CD8 Antigens Preferentially Restricted by HLA-B
por: Lewinsohn, Deborah A, et al.
Publicado: (2007)

Human rhinovirus‐specific CD8 T cell responses target conserved and unusual epitopes
por: Gomez‐Perosanz, Marta, et al.
Publicado: (2020)

Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8(+)T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii
por: Cong, Hua, et al.
Publicado: (2010)

Non-antigenic and antigenic interventions in type 1 diabetes
por: Rydén, Anna KE, et al.
Publicado: (2013)

P17-24. Interfering overlapping epitopes contribute to the subdominance of an HLA-A2-restricted HIV Gag-specific epitope
por: Kan-Mitchell, J, et al.
Publicado: (2009)

Design and validation of HIV peptide pools for detection of HIV-specific CD4(+) and CD8(+) T cells
por: Al-kolla, Rita, et al.
Publicado: (2022)

Identification of Conserved and HLA Promiscuous DENV3 T-Cell Epitopes
por: Nascimento, Eduardo J. M., et al.
Publicado: (2013)

Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes
por: Heide, Janna, et al.
Publicado: (2019)

The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides
por: Schultz, Heidi S., et al.
Publicado: (2018)

CD8(+) T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis
por: Feizi, Neda, et al.
Publicado: (2021)

HLA-A*0201-restricted CD8(+) T-cell epitopes identified in dengue viruses
por: Duan, Zhi-Liang, et al.
Publicado: (2012)

AIDS virus–specific CD8(+) T lymphocytes against an immunodominant cryptic epitope select for viral escape
por: Maness, Nicholas J., et al.
Publicado: (2007)

Predicting HLA CD4 Immunogenicity in Human Populations
por: Dhanda, Sandeep Kumar, et al.
Publicado: (2018)

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
por: Bender, Christine, et al.
Publicado: (2021)

Identification of HLA‐A*11:01‐restricted Mycobacterium tuberculosis CD8(+) T cell epitopes
por: Liu, Su‐Dong, et al.
Publicado: (2016)

Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
por: Bui, Huynh-Hoa, et al.
Publicado: (2007)

Reverse Genetics Modification of Cytomegalovirus Antigenicity and Immunogenicity by CD8 T-Cell Epitope Deletion and Insertion
por: Lemmermann, Niels A. W., et al.
Publicado: (2011)

Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
por: Neto, Tertuliano Alves Pereira, et al.
Publicado: (2023)

Characterization of Conserved and Promiscuous Human Rhinovirus CD4 T Cell Epitopes
por: Gomez-Perosanz, Marta, et al.
Publicado: (2021)

CD8(+) T-cell recognition of a synthetic epitope formed by t-butyl modification
por: Reid, Reiss A, et al.
Publicado: (2015)

Correction: Correlative CD4 and CD8 T-cell immunodominance in humans and mice: implications for preclinical testing
por: Neto, Tertuliano Alves Pereira, et al.
Publicado: (2023)

Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV
por: Chiu, Christopher, et al.
Publicado: (2014)

Conserved epitopes with high HLA-I population coverage are targets of CD8(+) T cells associated with high IFN-γ responses against all dengue virus serotypes
por: Adikari, Thiruni N., et al.
Publicado: (2020)

Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity
por: von Herrath, Matthias G., et al.
Publicado: (2005)

Chemical Modification of Influenza CD8+ T-Cell Epitopes Enhances Their Immunogenicity Regardless of Immunodominance
por: Rosendahl Huber, Sietske K., et al.
Publicado: (2016)

T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes
por: Juedes, Amy E., et al.
Publicado: (2004)

Identification of a First Human Norovirus CD8(+) T Cell Epitope Restricted to HLA-A(*)0201 Allele
por: Malm, Maria, et al.
Publicado: (2018)

HLA class I supertypes: a revised and updated classification
por: Sidney, John, et al.
Publicado: (2008)

Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA‐DQ2.5
por: Koşaloğlu‐Yalçın, Zeynep, et al.
Publicado: (2020)

Promiscuous Recognition of a Trypanosoma cruzi CD8(+) T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients
por: Lasso, Paola, et al.
Publicado: (2016)

Screening HLA-A-restricted T cell epitopes of SARS-CoV-2 and the induction of CD8(+) T cell responses in HLA-A transgenic mice
por: Jin, Xiaoxiao, et al.
Publicado: (2021)

Unusual Placement of an EBV Epitope into the Groove of the Ankylosing Spondylitis-Associated HLA-B27 Allele Allows CD8+ T Cell Activation
por: Tedeschi, Valentina, et al.
Publicado: (2019)

IMMUNOCAT—A Data Management System for Epitope Mapping Studies
por: Chung, Jo L., et al.
Publicado: (2010)

Increased Memory Conversion of Naïve CD8 T Cells Activated during Late Phases of Acute Virus Infection Due to Decreased Cumulative Antigen Exposure
por: Fousteri, Georgia, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4qrd2gjp03m27kni6e7h3vcse6