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The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study
Individuals suffering from obsessive-compulsive disorder (OCD) have been found to show deficits in implicitly learning probabilistic associations between events. Neuroimaging studies have associated these implicit learning deficits in OCD individuals with aberrant activation of the striatal system....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863501/ https://www.ncbi.nlm.nih.gov/pubmed/29599726 http://dx.doi.org/10.3389/fpsyt.2018.00058 |
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author | Hansmeier, Jana Exner, Cornelia Zetsche, Ulrike Jansen, Andreas |
author_facet | Hansmeier, Jana Exner, Cornelia Zetsche, Ulrike Jansen, Andreas |
author_sort | Hansmeier, Jana |
collection | PubMed |
description | Individuals suffering from obsessive-compulsive disorder (OCD) have been found to show deficits in implicitly learning probabilistic associations between events. Neuroimaging studies have associated these implicit learning deficits in OCD individuals with aberrant activation of the striatal system. Recent behavioral studies have highlighted that probabilistic classification learning (PCL) deficits in OCD individuals only occur in a disorder-specific context, while PCL remains intact in a neutral context. The neural correlates of implicit learning in an OCD-specific context, however, have not yet been investigated. Using functional magnetic resonance imaging during a neutral (prediction of weather) and an OCD-specific variant (prediction of a virus epidemic) of a PCL paradigm, we assessed brain activity associated with implicit learning processes in 10 participants with OCD and 10 matched healthy controls. Regions of interest (ROIs) were the striatum and the medial temporal lobe. ROI analyses revealed a significantly higher activity in the bilateral putamen and the left hippocampus of OCD participants as compared to healthy controls during both PCL tasks. The group differences could partly be subsumed under a group × task interaction effect with OCD participants showing a significantly higher activity than healthy controls in the left putamen and the left hippocampus in the OCD-specific task variant only. These results suggest a compensation of aberrant striatal activity by an augmented engagement of the explicit memory system particularly in a disorder-relevant context in OCD participants. |
format | Online Article Text |
id | pubmed-5863501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58635012018-03-29 The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study Hansmeier, Jana Exner, Cornelia Zetsche, Ulrike Jansen, Andreas Front Psychiatry Psychiatry Individuals suffering from obsessive-compulsive disorder (OCD) have been found to show deficits in implicitly learning probabilistic associations between events. Neuroimaging studies have associated these implicit learning deficits in OCD individuals with aberrant activation of the striatal system. Recent behavioral studies have highlighted that probabilistic classification learning (PCL) deficits in OCD individuals only occur in a disorder-specific context, while PCL remains intact in a neutral context. The neural correlates of implicit learning in an OCD-specific context, however, have not yet been investigated. Using functional magnetic resonance imaging during a neutral (prediction of weather) and an OCD-specific variant (prediction of a virus epidemic) of a PCL paradigm, we assessed brain activity associated with implicit learning processes in 10 participants with OCD and 10 matched healthy controls. Regions of interest (ROIs) were the striatum and the medial temporal lobe. ROI analyses revealed a significantly higher activity in the bilateral putamen and the left hippocampus of OCD participants as compared to healthy controls during both PCL tasks. The group differences could partly be subsumed under a group × task interaction effect with OCD participants showing a significantly higher activity than healthy controls in the left putamen and the left hippocampus in the OCD-specific task variant only. These results suggest a compensation of aberrant striatal activity by an augmented engagement of the explicit memory system particularly in a disorder-relevant context in OCD participants. Frontiers Media S.A. 2018-02-28 /pmc/articles/PMC5863501/ /pubmed/29599726 http://dx.doi.org/10.3389/fpsyt.2018.00058 Text en Copyright © 2018 Hansmeier, Exner, Zetsche and Jansen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Hansmeier, Jana Exner, Cornelia Zetsche, Ulrike Jansen, Andreas The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title | The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title_full | The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title_fullStr | The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title_full_unstemmed | The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title_short | The Neural Correlates of Probabilistic Classification Learning in Obsessive-Compulsive Disorder: A Pilot Study |
title_sort | neural correlates of probabilistic classification learning in obsessive-compulsive disorder: a pilot study |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863501/ https://www.ncbi.nlm.nih.gov/pubmed/29599726 http://dx.doi.org/10.3389/fpsyt.2018.00058 |
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