Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs

Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver...

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Detalles Bibliográficos
Autores principales: Khurana, Chandni, Chudasama, Bhupendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863621/
https://www.ncbi.nlm.nih.gov/pubmed/29593387
http://dx.doi.org/10.2147/IJN.S124698
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author Khurana, Chandni
Chudasama, Bhupendra
author_facet Khurana, Chandni
Chudasama, Bhupendra
author_sort Khurana, Chandni
collection PubMed
description Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver nanoparticles (SNPs) and CNPs exists. In this article, a comparative study on microbial properties of engineered metal nanoantibiotics against clinically important strains has been attempted. Our results indicate that biocidal activities of CNPs are better than SNPs. Minimum inhibitory concentration (MIC) values of CNPs are 10 times lower than the corresponding MICs of SNPs. These improved biocidal activities of CNPs would make it affordable and potent nontraditional antibiotics against which microbes are least susceptible to develop any drug resistance.
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spelling pubmed-58636212018-03-28 Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs Khurana, Chandni Chudasama, Bhupendra Int J Nanomedicine Short Report Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver nanoparticles (SNPs) and CNPs exists. In this article, a comparative study on microbial properties of engineered metal nanoantibiotics against clinically important strains has been attempted. Our results indicate that biocidal activities of CNPs are better than SNPs. Minimum inhibitory concentration (MIC) values of CNPs are 10 times lower than the corresponding MICs of SNPs. These improved biocidal activities of CNPs would make it affordable and potent nontraditional antibiotics against which microbes are least susceptible to develop any drug resistance. Dove Medical Press 2018-03-15 /pmc/articles/PMC5863621/ /pubmed/29593387 http://dx.doi.org/10.2147/IJN.S124698 Text en © 2018 Khurana and Chudasama. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Khurana, Chandni
Chudasama, Bhupendra
Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title_full Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title_fullStr Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title_full_unstemmed Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title_short Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
title_sort nanoantibiotics: strategic assets in the fight against drug-resistant superbugs
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863621/
https://www.ncbi.nlm.nih.gov/pubmed/29593387
http://dx.doi.org/10.2147/IJN.S124698
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AT chudasamabhupendra nanoantibioticsstrategicassetsinthefightagainstdrugresistantsuperbugs

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