Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle

Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantl...

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Autores principales: Kansara, Krupa, Patel, Pal, Shukla, Ritesh K, Pandya, Alok, Shanker, Rishi, Kumar, Ashutosh, Dhawan, Alok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863622/
https://www.ncbi.nlm.nih.gov/pubmed/29593401
http://dx.doi.org/10.2147/IJN.S124708
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author Kansara, Krupa
Patel, Pal
Shukla, Ritesh K
Pandya, Alok
Shanker, Rishi
Kumar, Ashutosh
Dhawan, Alok
author_facet Kansara, Krupa
Patel, Pal
Shukla, Ritesh K
Pandya, Alok
Shanker, Rishi
Kumar, Ashutosh
Dhawan, Alok
author_sort Kansara, Krupa
collection PubMed
description Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery.
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spelling pubmed-58636222018-03-28 Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle Kansara, Krupa Patel, Pal Shukla, Ritesh K Pandya, Alok Shanker, Rishi Kumar, Ashutosh Dhawan, Alok Int J Nanomedicine Short Report Over the last decade, there has been growing interest in developing novel nanoparticles (NPs) for biomedical applications. A safe-by-design approach was used in this study to synthesize biocompatible iron oxide NPs. The size of the particles obtained was ~100 nm. Although these NPs were significantly (P<0.05) internalized in MCF-7 (human breast adenocarcinoma cell line) cells, no adverse effect was observed in the cells as assessed by cytotoxicity assays (neutral red uptake and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) and cell cycle analysis. Our data demonstrate the potential of iron oxide NPs as a biocompatible carrier for targeted drug delivery. Dove Medical Press 2018-03-15 /pmc/articles/PMC5863622/ /pubmed/29593401 http://dx.doi.org/10.2147/IJN.S124708 Text en © 2018 Kansara et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Kansara, Krupa
Patel, Pal
Shukla, Ritesh K
Pandya, Alok
Shanker, Rishi
Kumar, Ashutosh
Dhawan, Alok
Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_full Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_fullStr Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_full_unstemmed Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_short Synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
title_sort synthesis of biocompatible iron oxide nanoparticles as a drug delivery vehicle
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863622/
https://www.ncbi.nlm.nih.gov/pubmed/29593401
http://dx.doi.org/10.2147/IJN.S124708
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