Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional...

Descripción completa

Detalles Bibliográficos
Autores principales: Baronia, Richa, Singh, Manjri, Gupta, Rajat B, Karuppiah, Stalin, Kumar, Rajiv, Belz, Jodi, Shanker, Rishi, Sridhar, Srinivas, Singh, Surinder P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863625/
https://www.ncbi.nlm.nih.gov/pubmed/29593408
http://dx.doi.org/10.2147/IJN.S125006
Descripción
Sumario:Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines.

Ejemplares similares