Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional...

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Autores principales: Baronia, Richa, Singh, Manjri, Gupta, Rajat B, Karuppiah, Stalin, Kumar, Rajiv, Belz, Jodi, Shanker, Rishi, Sridhar, Srinivas, Singh, Surinder P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863625/
https://www.ncbi.nlm.nih.gov/pubmed/29593408
http://dx.doi.org/10.2147/IJN.S125006
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author Baronia, Richa
Singh, Manjri
Gupta, Rajat B
Karuppiah, Stalin
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Sridhar, Srinivas
Singh, Surinder P
author_facet Baronia, Richa
Singh, Manjri
Gupta, Rajat B
Karuppiah, Stalin
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Sridhar, Srinivas
Singh, Surinder P
author_sort Baronia, Richa
collection PubMed
description Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines.
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spelling pubmed-58636252018-03-28 Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy Baronia, Richa Singh, Manjri Gupta, Rajat B Karuppiah, Stalin Kumar, Rajiv Belz, Jodi Shanker, Rishi Sridhar, Srinivas Singh, Surinder P Int J Nanomedicine Short Report Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines. Dove Medical Press 2018-03-15 /pmc/articles/PMC5863625/ /pubmed/29593408 http://dx.doi.org/10.2147/IJN.S125006 Text en © 2018 Baronia et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Baronia, Richa
Singh, Manjri
Gupta, Rajat B
Karuppiah, Stalin
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Sridhar, Srinivas
Singh, Surinder P
Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_full Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_fullStr Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_full_unstemmed Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_short Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
title_sort synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863625/
https://www.ncbi.nlm.nih.gov/pubmed/29593408
http://dx.doi.org/10.2147/IJN.S125006
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