In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines

We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed t...

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Detalles Bibliográficos
Autores principales: Singh, Manjri, Gupta, Parul, Baronia, Richa, Singh, Priti, Karuppiah, Stalin, Shankar, Rishi, Dwivedi, Premendra D, Singh, Surinder P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863627/
https://www.ncbi.nlm.nih.gov/pubmed/29593407
http://dx.doi.org/10.2147/IJN.S124891
Descripción
Sumario:We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer.

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