In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines

We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed t...

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Autores principales: Singh, Manjri, Gupta, Parul, Baronia, Richa, Singh, Priti, Karuppiah, Stalin, Shankar, Rishi, Dwivedi, Premendra D, Singh, Surinder P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863627/
https://www.ncbi.nlm.nih.gov/pubmed/29593407
http://dx.doi.org/10.2147/IJN.S124891
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author Singh, Manjri
Gupta, Parul
Baronia, Richa
Singh, Priti
Karuppiah, Stalin
Shankar, Rishi
Dwivedi, Premendra D
Singh, Surinder P
author_facet Singh, Manjri
Gupta, Parul
Baronia, Richa
Singh, Priti
Karuppiah, Stalin
Shankar, Rishi
Dwivedi, Premendra D
Singh, Surinder P
author_sort Singh, Manjri
collection PubMed
description We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer.
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spelling pubmed-58636272018-03-28 In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines Singh, Manjri Gupta, Parul Baronia, Richa Singh, Priti Karuppiah, Stalin Shankar, Rishi Dwivedi, Premendra D Singh, Surinder P Int J Nanomedicine Short Report We have synthesized graphene oxide (GO) nanosheets using modified Hummer’s method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO–DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO–DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO–DOx drug conjugate for head and neck cancer. Dove Medical Press 2018-03-15 /pmc/articles/PMC5863627/ /pubmed/29593407 http://dx.doi.org/10.2147/IJN.S124891 Text en © 2018 Singh et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Singh, Manjri
Gupta, Parul
Baronia, Richa
Singh, Priti
Karuppiah, Stalin
Shankar, Rishi
Dwivedi, Premendra D
Singh, Surinder P
In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_full In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_fullStr In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_full_unstemmed In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_short In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
title_sort in vitro cytotoxicity of go–dox on fadu squamous carcinoma cell lines
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863627/
https://www.ncbi.nlm.nih.gov/pubmed/29593407
http://dx.doi.org/10.2147/IJN.S124891
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