Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer

Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accompl...

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Autores principales: Gupta, Parul, Singh, Manjri, Kumar, Rajiv, Belz, Jodi, Shanker, Rishi, Dwivedi, Premendra D, Sridhar, Srinivas, Singh, Surinder P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863638/
https://www.ncbi.nlm.nih.gov/pubmed/29593398
http://dx.doi.org/10.2147/IJN.S124995
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author Gupta, Parul
Singh, Manjri
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Dwivedi, Premendra D
Sridhar, Srinivas
Singh, Surinder P
author_facet Gupta, Parul
Singh, Manjri
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Dwivedi, Premendra D
Sridhar, Srinivas
Singh, Surinder P
author_sort Gupta, Parul
collection PubMed
description Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629).
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spelling pubmed-58636382018-03-28 Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer Gupta, Parul Singh, Manjri Kumar, Rajiv Belz, Jodi Shanker, Rishi Dwivedi, Premendra D Sridhar, Srinivas Singh, Surinder P Int J Nanomedicine Short Report Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629). Dove Medical Press 2018-03-15 /pmc/articles/PMC5863638/ /pubmed/29593398 http://dx.doi.org/10.2147/IJN.S124995 Text en © 2018 Gupta et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Short Report
Gupta, Parul
Singh, Manjri
Kumar, Rajiv
Belz, Jodi
Shanker, Rishi
Dwivedi, Premendra D
Sridhar, Srinivas
Singh, Surinder P
Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_full Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_fullStr Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_full_unstemmed Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_short Synthesis and in vitro studies of PLGA-DTX nanoconjugate as potential drug delivery vehicle for oral cancer
title_sort synthesis and in vitro studies of plga-dtx nanoconjugate as potential drug delivery vehicle for oral cancer
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863638/
https://www.ncbi.nlm.nih.gov/pubmed/29593398
http://dx.doi.org/10.2147/IJN.S124995
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