New Vaccine Formulations Containing a Modified Version of the Amastigote 2 Antigen and the Non-Virulent Trypanosoma cruzi CL-14 Strain Are Highly Antigenic and Protective against Leishmania infantum Challenge

Visceral leishmaniasis (VL) is a major public health issue reported as the second illness in mortality among all tropical diseases. Clinical trials have shown that protection against VL is associated with robust T cell responses, especially those producing IFN-γ. The Leishmania amastigote 2 (A2) pro...

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Detalles Bibliográficos
Autores principales: Almeida, Ana Paula M. M., Machado, Leopoldo F. M., Doro, Daniel, Nascimento, Frederico C., Damasceno, Leonardo, Gazzinelli, Ricardo Tostes, Fernandes, Ana Paula, Junqueira, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863692/
https://www.ncbi.nlm.nih.gov/pubmed/29599776
http://dx.doi.org/10.3389/fimmu.2018.00465

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