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MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma
BACKGROUND & AIMS: Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new therapeutic agents are needed. We performed a screen to identify small-molecule compounds that are active against CCAs. Levels of microRNA 21 (MIR21 or miRNA21) are increased in CCAs. We investigated whether miRNA...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
W.B. Saunders
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863695/ https://www.ncbi.nlm.nih.gov/pubmed/29113809 http://dx.doi.org/10.1053/j.gastro.2017.10.043 |