STAT3, stem cells, cancer stem cells and p63

Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditi...

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Detalles Bibliográficos
Autores principales: Galoczova, Michaela, Coates, Philip, Vojtesek, Borivoj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863838/
https://www.ncbi.nlm.nih.gov/pubmed/29588647
http://dx.doi.org/10.1186/s11658-018-0078-0
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author Galoczova, Michaela
Coates, Philip
Vojtesek, Borivoj
author_facet Galoczova, Michaela
Coates, Philip
Vojtesek, Borivoj
author_sort Galoczova, Michaela
collection PubMed
description Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its role in stem cell and cancer stem cell properties and highlights recent reports about its relationship to p63.
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spelling pubmed-58638382018-03-27 STAT3, stem cells, cancer stem cells and p63 Galoczova, Michaela Coates, Philip Vojtesek, Borivoj Cell Mol Biol Lett Review Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its role in stem cell and cancer stem cell properties and highlights recent reports about its relationship to p63. BioMed Central 2018-03-22 /pmc/articles/PMC5863838/ /pubmed/29588647 http://dx.doi.org/10.1186/s11658-018-0078-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Galoczova, Michaela
Coates, Philip
Vojtesek, Borivoj
STAT3, stem cells, cancer stem cells and p63
title STAT3, stem cells, cancer stem cells and p63
title_full STAT3, stem cells, cancer stem cells and p63
title_fullStr STAT3, stem cells, cancer stem cells and p63
title_full_unstemmed STAT3, stem cells, cancer stem cells and p63
title_short STAT3, stem cells, cancer stem cells and p63
title_sort stat3, stem cells, cancer stem cells and p63
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863838/
https://www.ncbi.nlm.nih.gov/pubmed/29588647
http://dx.doi.org/10.1186/s11658-018-0078-0
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AT vojtesekborivoj stat3stemcellscancerstemcellsandp63

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