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Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer

BACKGROUND: Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressors in breast cancer. While PTEN itself is not considered a druggable target, PTEN synthetic-sick or synthetic-lethal (PTEN-SSL) genes are potential drug targets in PTEN-deficient breast cancers...

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Detalles Bibliográficos
Autores principales:	Tang, Yew Chung, Ho, Szu-Chi, Tan, Elisabeth, Ng, Alvin Wei Tian, McPherson, John R., Goh, Germaine Yen Lin, Teh, Bin Tean, Bard, Frederic, Rozen, Steven G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863852/ https://www.ncbi.nlm.nih.gov/pubmed/29566768 http://dx.doi.org/10.1186/s13058-018-0949-3

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