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Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men
BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio va...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863945/ https://www.ncbi.nlm.nih.gov/pubmed/29565984 http://dx.doi.org/10.1371/journal.pone.0193191 |
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author | Lee, Jung Eun Lee, Yong Jae Chung, Soo Yoon Cho, Hee Woo Park, Byoung Jin Jung, Dong Hyuk |
author_facet | Lee, Jung Eun Lee, Yong Jae Chung, Soo Yoon Cho, Hee Woo Park, Byoung Jin Jung, Dong Hyuk |
author_sort | Lee, Jung Eun |
collection | PubMed |
description | BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution—magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20–70 years. RESULTS: A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054–1.081, p < 0.001), body mass index (OR 1.120; 1.08 0–1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001–1.023, p = 0.027; OR 1.006; 1.001–1.012, p = 0.036), fasting glucose (OR 1.021; 1.015–1.027, p < 0.001), triglycerides (OR 1.002; 1.000–1.003, p = 0.016), hypertension (OR 2.836; 2.268–3.546, p < 0.001), and diabetes (OR 2.911; 2.137–3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965–0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89). CONCLUSIONS: Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA. |
format | Online Article Text |
id | pubmed-5863945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58639452018-03-28 Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men Lee, Jung Eun Lee, Yong Jae Chung, Soo Yoon Cho, Hee Woo Park, Byoung Jin Jung, Dong Hyuk PLoS One Research Article BACKGROUND: No studies have reported the relationship between nonalcoholic fatty liver disease (NAFLD) and concurrent cerebral artery and coronary artery atherosclerosis simultaneously. We aimed at determining whether NAFLD, as assessed by ultrasound, is associated with subclinical cerebro-cardio vascular atherosclerosis (CCVA) by multidetector-row computed tomography (MDCT), and high resolution—magnetic resonance angiography (HR-MRA). This cross-sectional study included men in the general Korean population aged 20–70 years. RESULTS: A total of 1,652 men participated in the study (normal, n = 835; mild-to-moderate NAFLD, n = 512; severe NAFLD, n = 305). The risk of subclinical CCVA was positively associated with age (odds ratio [OR] 1.068; 1.054–1.081, p < 0.001), body mass index (OR 1.120; 1.08 0–1.162, p < 0.001), hepatic enzyme levels (OR 1.012; 1.001–1.023, p = 0.027; OR 1.006; 1.001–1.012, p = 0.036), fasting glucose (OR 1.021; 1.015–1.027, p < 0.001), triglycerides (OR 1.002; 1.000–1.003, p = 0.016), hypertension (OR 2.836; 2.268–3.546, p < 0.001), and diabetes (OR 2.911; 2.137–3.964, p < 0.001). Also, high-density lipoprotein cholesterol was inversely associated with subclinical CCVA (OR 0.974; 0.965–0.982, p < 0.001). Compared with normal controls, the OR for subclinical CCVA after full adjustment was 1.46 in the mild-to-moderate NAFLD group (95% confidence interval [CI]: 1.10 to 1.93) and 2.04 in the severe NAFLD group (95% CI: 1.44 to 2.89). CONCLUSIONS: Our data show that NAFLD is common among Korean men, and NAFLD severity on ultrasonography is associated with subclinical CCVA, as assessed by MDCT, and HR-MRA. Public Library of Science 2018-03-22 /pmc/articles/PMC5863945/ /pubmed/29565984 http://dx.doi.org/10.1371/journal.pone.0193191 Text en © 2018 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Jung Eun Lee, Yong Jae Chung, Soo Yoon Cho, Hee Woo Park, Byoung Jin Jung, Dong Hyuk Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title_full | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title_fullStr | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title_full_unstemmed | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title_short | Severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in Korean men |
title_sort | severity of nonalcoholic fatty liver disease is associated with subclinical cerebro-cardiovascular atherosclerosis risk in korean men |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863945/ https://www.ncbi.nlm.nih.gov/pubmed/29565984 http://dx.doi.org/10.1371/journal.pone.0193191 |
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