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Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons

Amyloid aggregates of the protein α-synuclein (αS) called Lewy Bodies (LB) and Lewy Neurites (LN) are the pathological hallmark of Parkinson’s disease (PD) and other synucleinopathies. We have previously shown that high extracellular αS concentrations can be toxic to cells and that neurons take up α...

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Detalles Bibliográficos
Autores principales:	Hassink, G. C., Raiss, C. C., Segers-Nolten, I. M. J., van Wezel, R. J. A., Subramaniam, V., le Feber, J., Claessens, M. M. A. E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863964/ https://www.ncbi.nlm.nih.gov/pubmed/29565978 http://dx.doi.org/10.1371/journal.pone.0193763

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