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Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells

Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome. Mild hypothermia has been established as an effective strategy to enhance protein specific product...

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Detalles Bibliográficos
Autores principales:	Torres, Mauro, Zúñiga, Roberto, Gutierrez, Matias, Vergara, Mauricio, Collazo, Norberto, Reyes, Juan, Berrios, Julio, Aguillon, Juan Carlos, Molina, Maria Carmen, Altamirano, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864046/ https://www.ncbi.nlm.nih.gov/pubmed/29566086 http://dx.doi.org/10.1371/journal.pone.0194510

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