Sumoylation of Notch1 represses its target gene expression during cell stress

The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand binding, production of the Notch...

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Detalles Bibliográficos
Autores principales: Antila, Christian J. M., Rraklli, Vilma, Blomster, Henri A., Dahlström, Käthe M., Salminen, Tiina A., Holmberg, Johan, Sistonen, Lea, Sahlgren, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864205/
https://www.ncbi.nlm.nih.gov/pubmed/29305585
http://dx.doi.org/10.1038/s41418-017-0002-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864205/
https://www.ncbi.nlm.nih.gov/pubmed/29305585
http://dx.doi.org/10.1038/s41418-017-0002-6

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