Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice

A key regulatory gene in definitive erythropoiesis is the transcription factor Krüppel-like factor 1 (Klf1). Klf1 null mice die in utero by day 15.5 (E15.5) due to impaired definitive erythropoiesis and severe anemia. Definitive erythropoiesis takes place in erythroblastic islands in mammals. Erythr...

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Detalles Bibliográficos
Autores principales: Manchinu, Maria Francesca, Brancia, Carla, Caria, Cristian Antonio, Musu, Ester, Porcu, Susanna, Simbula, Michela, Asunis, Isadora, Perseu, Lucia, Ristaldi, Maria Serafina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864211/
https://www.ncbi.nlm.nih.gov/pubmed/29230002
http://dx.doi.org/10.1038/s41418-017-0003-5

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