Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis

Heme is required for cell respiration and survival. Nevertheless, its intracellular levels need to be finely regulated to avoid heme excess, which may catalyze the production of reactive oxygen species (ROS) and promote cell death. Here, we show that alteration of heme homeostasis in endothelial cel...

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Detalles Bibliográficos
Autores principales: Petrillo, Sara, Chiabrando, Deborah, Genova, Tullio, Fiorito, Veronica, Ingoglia, Giada, Vinchi, Francesca, Mussano, Federico, Carossa, Stefano, Silengo, Lorenzo, Altruda, Fiorella, Merlo, Giorgio Roberto, Munaron, Luca, Tolosano, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864215/
https://www.ncbi.nlm.nih.gov/pubmed/29229999
http://dx.doi.org/10.1038/s41418-017-0001-7

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