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Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review

The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, w...

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Detalles Bibliográficos
Autores principales: Ming, Yu, Zecevic, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Canadian Geriatrics Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864570/
https://www.ncbi.nlm.nih.gov/pubmed/29581817
http://dx.doi.org/10.5770/cgj.21.268
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author Ming, Yu
Zecevic, Aleksandra
author_facet Ming, Yu
Zecevic, Aleksandra
author_sort Ming, Yu
collection PubMed
description The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1.5–2 times higher possibility of recurrent falls in older adults. As a high-risk group, recurrent fallers require meaningful intervention. Medications are believed to be a modifiable risk factor in falls prevention; hence, special consideration should be taken to balance the benefit and harm in initiating, continuing or increasing certain classes of medications in elderly recurrent fallers.
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spelling pubmed-58645702018-03-26 Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review Ming, Yu Zecevic, Aleksandra Can Geriatr J Systemic Reviews/Meta-Analysis The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1.5–2 times higher possibility of recurrent falls in older adults. As a high-risk group, recurrent fallers require meaningful intervention. Medications are believed to be a modifiable risk factor in falls prevention; hence, special consideration should be taken to balance the benefit and harm in initiating, continuing or increasing certain classes of medications in elderly recurrent fallers. Canadian Geriatrics Society 2018-03-26 /pmc/articles/PMC5864570/ /pubmed/29581817 http://dx.doi.org/10.5770/cgj.21.268 Text en © 2018 Author(s). Published by the Canadian Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No-Derivative license (http://creativecommons.org/licenses/by-nc-nd/2.5/ca/), which permits unrestricted non-commercial use and distribution, provided the original work is properly cited.
spellingShingle Systemic Reviews/Meta-Analysis
Ming, Yu
Zecevic, Aleksandra
Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title_full Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title_fullStr Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title_full_unstemmed Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title_short Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
title_sort medications & polypharmacy influence on recurrent fallers in community: a systematic review
topic Systemic Reviews/Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864570/
https://www.ncbi.nlm.nih.gov/pubmed/29581817
http://dx.doi.org/10.5770/cgj.21.268
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