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Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review
The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, w...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Canadian Geriatrics Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864570/ https://www.ncbi.nlm.nih.gov/pubmed/29581817 http://dx.doi.org/10.5770/cgj.21.268 |
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author | Ming, Yu Zecevic, Aleksandra |
author_facet | Ming, Yu Zecevic, Aleksandra |
author_sort | Ming, Yu |
collection | PubMed |
description | The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1.5–2 times higher possibility of recurrent falls in older adults. As a high-risk group, recurrent fallers require meaningful intervention. Medications are believed to be a modifiable risk factor in falls prevention; hence, special consideration should be taken to balance the benefit and harm in initiating, continuing or increasing certain classes of medications in elderly recurrent fallers. |
format | Online Article Text |
id | pubmed-5864570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Canadian Geriatrics Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-58645702018-03-26 Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review Ming, Yu Zecevic, Aleksandra Can Geriatr J Systemic Reviews/Meta-Analysis The purpose of this systematic review is to summarize information about the impact different classes of medications and polypharmacy have on recurrent falls, defined as two or more falls in a 12-month period, in community-dwelling older adults. After adjustment for confounders such as age, gender, weight or depression symptoms, the reviewed studies suggested that older adults who use antidepressants, sedatives or hypnotics and anti-epileptics were more likely to experience recurrent falls than non-users. Polypharmacy (use of four or more prescription medications daily) caused 1.5–2 times higher possibility of recurrent falls in older adults. As a high-risk group, recurrent fallers require meaningful intervention. Medications are believed to be a modifiable risk factor in falls prevention; hence, special consideration should be taken to balance the benefit and harm in initiating, continuing or increasing certain classes of medications in elderly recurrent fallers. Canadian Geriatrics Society 2018-03-26 /pmc/articles/PMC5864570/ /pubmed/29581817 http://dx.doi.org/10.5770/cgj.21.268 Text en © 2018 Author(s). Published by the Canadian Geriatrics Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No-Derivative license (http://creativecommons.org/licenses/by-nc-nd/2.5/ca/), which permits unrestricted non-commercial use and distribution, provided the original work is properly cited. |
spellingShingle | Systemic Reviews/Meta-Analysis Ming, Yu Zecevic, Aleksandra Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title | Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title_full | Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title_fullStr | Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title_full_unstemmed | Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title_short | Medications & Polypharmacy Influence on Recurrent Fallers in Community: a Systematic Review |
title_sort | medications & polypharmacy influence on recurrent fallers in community: a systematic review |
topic | Systemic Reviews/Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864570/ https://www.ncbi.nlm.nih.gov/pubmed/29581817 http://dx.doi.org/10.5770/cgj.21.268 |
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