Immunomodulator effect of topical zinc oxide application in tuberculin skin test

OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6–14 years, and plasma zinc levels were analyzed after 10–12 hour...

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Autores principales: Nuhoglu, Cagatay, Hepkaya, Evrim, Onal, Zehra Esra, Akici, Narin, Gurbuz, Tamay, Atasayan, Vildan, Ceran, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864705/
https://www.ncbi.nlm.nih.gov/pubmed/29607430
http://dx.doi.org/10.14744/nci.2017.88896
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author Nuhoglu, Cagatay
Hepkaya, Evrim
Onal, Zehra Esra
Akici, Narin
Gurbuz, Tamay
Atasayan, Vildan
Ceran, Omer
author_facet Nuhoglu, Cagatay
Hepkaya, Evrim
Onal, Zehra Esra
Akici, Narin
Gurbuz, Tamay
Atasayan, Vildan
Ceran, Omer
author_sort Nuhoglu, Cagatay
collection PubMed
description OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6–14 years, and plasma zinc levels were analyzed after 10–12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis.
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spelling pubmed-58647052018-03-30 Immunomodulator effect of topical zinc oxide application in tuberculin skin test Nuhoglu, Cagatay Hepkaya, Evrim Onal, Zehra Esra Akici, Narin Gurbuz, Tamay Atasayan, Vildan Ceran, Omer North Clin Istanb Original Article OBJECTIVE: We aimed to evaluate the sensitivity of tuberculin skintest (purified protein derivative-PPD) by topical zinc application on test site to improve diagnostic reliability. METHODS: We performed this study in 100 children aged 6–14 years, and plasma zinc levels were analyzed after 10–12 hours fasting. After PPD, we applied 40% zinc oxide cream on one forearm and placebo on the other forearm. PPD indurations were measured 72 hours later. RESULTS: In this study, 26% of the children showed increases in PPD induration following local zinc applications. There was no correlation between indurations size and serum zinc levels. CONCLUSION: We concluded that topical zinc cream application can enhance sensitivity of tuberculin reactivityin the diagnosis of tuberculosis. Kare Publishing 2018-01-11 /pmc/articles/PMC5864705/ /pubmed/29607430 http://dx.doi.org/10.14744/nci.2017.88896 Text en Copyright: © 2018 by Istanbul Northern Anatolian Association of Public Hospitals http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Original Article
Nuhoglu, Cagatay
Hepkaya, Evrim
Onal, Zehra Esra
Akici, Narin
Gurbuz, Tamay
Atasayan, Vildan
Ceran, Omer
Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title_full Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title_fullStr Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title_full_unstemmed Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title_short Immunomodulator effect of topical zinc oxide application in tuberculin skin test
title_sort immunomodulator effect of topical zinc oxide application in tuberculin skin test
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864705/
https://www.ncbi.nlm.nih.gov/pubmed/29607430
http://dx.doi.org/10.14744/nci.2017.88896
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