Identification of p38 MAPK as a novel therapeutic target for Friedreich’s ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neuro- and cardio-degenerative disorder caused by decreased expression of frataxin, a protein that localizes to mitochondria and is critical for iron-sulfur-cluster (ISC) assembly. There are no proven effective treatments for FRDA. We previously scr...

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Detalles Bibliográficos
Autores principales: Cotticelli, M. Grazia, Xia, Shujuan, Kaur, Avinash, Lin, Daniel, Wang, Yongping, Ruff, Eric, Tobias, John W., Wilson, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864720/
https://www.ncbi.nlm.nih.gov/pubmed/29568068
http://dx.doi.org/10.1038/s41598-018-23168-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864720/
https://www.ncbi.nlm.nih.gov/pubmed/29568068
http://dx.doi.org/10.1038/s41598-018-23168-x

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