Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae

The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present study, we identified mutations corresponding to rifampin resistance in r...

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Detalles Bibliográficos
Autores principales: Vedithi, Sundeep Chaitanya, Malhotra, Sony, Das, Madhusmita, Daniel, Sheela, Kishore, Nanda, George, Anuja, Arumugam, Shantha, Rajan, Lakshmi, Ebenezer, Mannam, Ascher, David B., Arnold, Eddy, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864748/
https://www.ncbi.nlm.nih.gov/pubmed/29567948
http://dx.doi.org/10.1038/s41598-018-23423-1

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