Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria

We studied group-I metabotropic glutamate (mGlu) receptors in Pah(enu2) (ENU2) mice, which mimic the genetics and neurobiology of human phenylketonuria (PKU), a metabolic disorder characterized, if untreated, by autism, and intellectual disability (ID). Male ENU2 mice showed increased mGlu5 receptor...

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Detalles Bibliográficos
Autores principales: Nardecchia, Francesca, Orlando, Rosamaria, Iacovelli, Luisa, Colamartino, Marco, Fiori, Elena, Leuzzi, Vincenzo, Piccinin, Sonia, Nistico, Robert, Puglisi-Allegra, Stefano, Di Menna, Luisa, Battaglia, Giuseppe, Nicoletti, Ferdinando, Pascucci, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864888/
https://www.ncbi.nlm.nih.gov/pubmed/29615849
http://dx.doi.org/10.3389/fnins.2018.00154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864888/
https://www.ncbi.nlm.nih.gov/pubmed/29615849
http://dx.doi.org/10.3389/fnins.2018.00154

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