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Redox Aspects of Chaperones in Cardiac Function
Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864891/ https://www.ncbi.nlm.nih.gov/pubmed/29615920 http://dx.doi.org/10.3389/fphys.2018.00216 |
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author | Penna, Claudia Sorge, Matteo Femminò, Saveria Pagliaro, Pasquale Brancaccio, Mara |
author_facet | Penna, Claudia Sorge, Matteo Femminò, Saveria Pagliaro, Pasquale Brancaccio, Mara |
author_sort | Penna, Claudia |
collection | PubMed |
description | Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases including cancer, neurodegeneration, and cardiovascular diseases. Redox sensible post-translational modifications, such as S-nitrosylation, glutathionylation and phosphorylation of chaperone proteins have been reported. Redox-dependent regulation of chaperones is likely to be a phenomenon involved in metabolic processes and may represent an adaptive response to several stress conditions, especially within mitochondria, where it impacts cellular bioenergetics. These post-translational modifications might underlie the mechanisms leading to cardioprotection by conditioning maneuvers as well as to ischemia/reperfusion injury. In this review, we discuss this topic and focus on two important aspects of redox-regulated chaperones, namely redox regulation of mitochondrial chaperone function and cardiac protection against ischemia/reperfusion injury. |
format | Online Article Text |
id | pubmed-5864891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58648912018-04-03 Redox Aspects of Chaperones in Cardiac Function Penna, Claudia Sorge, Matteo Femminò, Saveria Pagliaro, Pasquale Brancaccio, Mara Front Physiol Physiology Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases including cancer, neurodegeneration, and cardiovascular diseases. Redox sensible post-translational modifications, such as S-nitrosylation, glutathionylation and phosphorylation of chaperone proteins have been reported. Redox-dependent regulation of chaperones is likely to be a phenomenon involved in metabolic processes and may represent an adaptive response to several stress conditions, especially within mitochondria, where it impacts cellular bioenergetics. These post-translational modifications might underlie the mechanisms leading to cardioprotection by conditioning maneuvers as well as to ischemia/reperfusion injury. In this review, we discuss this topic and focus on two important aspects of redox-regulated chaperones, namely redox regulation of mitochondrial chaperone function and cardiac protection against ischemia/reperfusion injury. Frontiers Media S.A. 2018-03-16 /pmc/articles/PMC5864891/ /pubmed/29615920 http://dx.doi.org/10.3389/fphys.2018.00216 Text en Copyright © 2018 Penna, Sorge, Femminò, Pagliaro and Brancaccio. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Penna, Claudia Sorge, Matteo Femminò, Saveria Pagliaro, Pasquale Brancaccio, Mara Redox Aspects of Chaperones in Cardiac Function |
title | Redox Aspects of Chaperones in Cardiac Function |
title_full | Redox Aspects of Chaperones in Cardiac Function |
title_fullStr | Redox Aspects of Chaperones in Cardiac Function |
title_full_unstemmed | Redox Aspects of Chaperones in Cardiac Function |
title_short | Redox Aspects of Chaperones in Cardiac Function |
title_sort | redox aspects of chaperones in cardiac function |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864891/ https://www.ncbi.nlm.nih.gov/pubmed/29615920 http://dx.doi.org/10.3389/fphys.2018.00216 |
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