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Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice

Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP(+) to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reduc...

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Detalles Bibliográficos
Autores principales:	White, Karessa, Kim, Mi-Jung, Han, Chul, Park, Hyo-Jin, Ding, Dalian, Boyd, Kevin, Walker, Logan, Linser, Paul, Meneses, Zaimary, Slade, Cole, Hirst, Jonathan, Santostefano, Katherine, Terada, Naohiro, Miyakawa, Takuya, Tanokura, Masaru, Salvi, Richard, Someya, Shinichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864918/ https://www.ncbi.nlm.nih.gov/pubmed/29567975 http://dx.doi.org/10.1038/s41598-018-23436-w

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