Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7). Transfer of antibodies against COL7 into mice results in a subepidermal blistering phenotype, strictly depending on the compl...

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Detalles Bibliográficos
Autores principales: Mihai, Sidonia, Hirose, Misa, Wang, Yi, Thurman, Joshua M., Holers, V. Michael, Morgan, B. Paul, Köhl, Jörg, Zillikens, Detlef, Ludwig, Ralf J., Nimmerjahn, Falk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865061/
https://www.ncbi.nlm.nih.gov/pubmed/29616034
http://dx.doi.org/10.3389/fimmu.2018.00535

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