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Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study

BACKGROUND: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bo...

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Autores principales: von Moos, Roger, Body, Jean-Jacques, Guenther, Oliver, Terpos, Evangelos, Acklin, Yves Pascal, Finek, Jindrich, Pereira, João, Maniadakis, Nikos, Hechmati, Guy, Talbot, Susan, Sleeboom, Harm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865076/
https://www.ncbi.nlm.nih.gov/pubmed/29577024
http://dx.doi.org/10.1016/j.jbo.2018.01.003
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author von Moos, Roger
Body, Jean-Jacques
Guenther, Oliver
Terpos, Evangelos
Acklin, Yves Pascal
Finek, Jindrich
Pereira, João
Maniadakis, Nikos
Hechmati, Guy
Talbot, Susan
Sleeboom, Harm
author_facet von Moos, Roger
Body, Jean-Jacques
Guenther, Oliver
Terpos, Evangelos
Acklin, Yves Pascal
Finek, Jindrich
Pereira, João
Maniadakis, Nikos
Hechmati, Guy
Talbot, Susan
Sleeboom, Harm
author_sort von Moos, Roger
collection PubMed
description BACKGROUND: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. METHODS: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period. RESULTS: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures. CONCLUSION: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients.
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spelling pubmed-58650762018-03-23 Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study von Moos, Roger Body, Jean-Jacques Guenther, Oliver Terpos, Evangelos Acklin, Yves Pascal Finek, Jindrich Pereira, João Maniadakis, Nikos Hechmati, Guy Talbot, Susan Sleeboom, Harm J Bone Oncol Research Article BACKGROUND: Bone metastases and lytic lesions due to multiple myeloma are common in advanced cancer and can lead to debilitating complications (skeletal-related events [SREs]), including requirement for radiation to bone. Despite the high frequency of radiation to bone in patients with metastatic bone disease, our knowledge of associated healthcare resource utilization (HRU) is limited. METHODS: This retrospective study estimated HRU following radiation to bone in Austria, the Czech Republic, Finland, Greece, Poland, Portugal, Sweden and Switzerland. Eligible patients were ≥ 20 years old, had bone metastases secondary to breast, lung or prostate cancer, or bone lesions associated with multiple myeloma, and had received radiation to bone between 1 July 2004 and 1 July 2009. HRU data were extracted from hospital patient charts from 3.5 months before the index SRE (radiation to bone preceded by a SRE-free period of ≥ 6.5 months) until 3 months after the last SRE that the patient experienced during the study period. RESULTS: In total, 482 patients were included. The number of inpatient stays increased from baseline by a mean of 0.52 (standard deviation [SD] 1.17) stays per radiation to bone event and the duration of stays increased by a mean of 7.8 (SD 14.8) days. Outpatient visits increased by a mean of 4.24 (SD 6.57) visits and procedures by a mean of 8.51 (SD 7.46) procedures. CONCLUSION: HRU increased following radiation to bone across all countries studied. Agents that prevent severe pain and delay the need for radiation have the potential to reduce the burden imposed on healthcare resources and patients. Elsevier 2018-02-05 /pmc/articles/PMC5865076/ /pubmed/29577024 http://dx.doi.org/10.1016/j.jbo.2018.01.003 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
von Moos, Roger
Body, Jean-Jacques
Guenther, Oliver
Terpos, Evangelos
Acklin, Yves Pascal
Finek, Jindrich
Pereira, João
Maniadakis, Nikos
Hechmati, Guy
Talbot, Susan
Sleeboom, Harm
Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title_full Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title_fullStr Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title_full_unstemmed Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title_short Healthcare-resource utilization associated with radiation to bone across eight European countries: Results from a retrospective study
title_sort healthcare-resource utilization associated with radiation to bone across eight european countries: results from a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865076/
https://www.ncbi.nlm.nih.gov/pubmed/29577024
http://dx.doi.org/10.1016/j.jbo.2018.01.003
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