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Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid depos...

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Detalles Bibliográficos
Autores principales:	Rainey-Smith, Stephanie R., Mazzucchelli, Gavin N., Villemagne, Victor L., Brown, Belinda M., Porter, Tenielle, Weinborn, Michael, Bucks, Romola S., Milicic, Lidija, Sohrabi, Hamid R., Taddei, Kevin, Ames, David, Maruff, Paul, Masters, Colin L., Rowe, Christopher C., Salvado, Olivier, Martins, Ralph N., Laws, Simon M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865132/ https://www.ncbi.nlm.nih.gov/pubmed/29479071 http://dx.doi.org/10.1038/s41398-018-0094-x

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