Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

Replication of mammalian mitochondrial DNA (mtDNA) is an essential process that requires high fidelity and control at multiple levels to ensure proper mitochondrial function. Mutations in the mitochondrial genome maintenance exonuclease 1 (MGME1) gene were recently reported in mitochondrial disease...

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Detalles Bibliográficos
Autores principales: Matic, Stanka, Jiang, Min, Nicholls, Thomas J., Uhler, Jay P., Dirksen-Schwanenland, Caren, Polosa, Paola Loguercio, Simard, Marie-Lune, Li, Xinping, Atanassov, Ilian, Rackham, Oliver, Filipovska, Aleksandra, Stewart, James B., Falkenberg, Maria, Larsson, Nils-Göran, Milenkovic, Dusanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865154/
https://www.ncbi.nlm.nih.gov/pubmed/29572490
http://dx.doi.org/10.1038/s41467-018-03552-x

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