Cargando…
A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task
Judgement bias tasks are promising tools to assess emotional valence in animals, however current designs are often time-consuming and lack aspects of validity. This study aimed to establish an improved design that addresses these issues and can be used across species. Horses, rats, and mice were tra...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865189/ https://www.ncbi.nlm.nih.gov/pubmed/29572529 http://dx.doi.org/10.1038/s41598-018-23459-3 |
_version_ | 1783308638365941760 |
---|---|
author | Hintze, Sara Melotti, Luca Colosio, Simona Bailoo, Jeremy D. Boada-Saña, Maria Würbel, Hanno Murphy, Eimear |
author_facet | Hintze, Sara Melotti, Luca Colosio, Simona Bailoo, Jeremy D. Boada-Saña, Maria Würbel, Hanno Murphy, Eimear |
author_sort | Hintze, Sara |
collection | PubMed |
description | Judgement bias tasks are promising tools to assess emotional valence in animals, however current designs are often time-consuming and lack aspects of validity. This study aimed to establish an improved design that addresses these issues and can be used across species. Horses, rats, and mice were trained on a spatial Go/No-go task where animals could initiate each trial. The location of an open goal-box, at either end of a row of five goal-boxes, signalled either reward (positive trial) or non-reward (negative trial). Animals first learned to approach the goal-box in positive trials (Go) and to re-initiate/not approach in negative trials (No-go). Animals were then tested for responses to ambiguous trials where goal-boxes at intermediate locations were opened. The Go:No-go response ratio was used as a measure of judgement bias. Most animals quickly learned the Go/No-go discrimination and performed trials at a high rate compared to previous studies. Subjects of all species reliably discriminated between reference cues and ambiguous cues, demonstrating a monotonic graded response across the different cue locations, with no evidence of learning about the outcome of ambiguous trials. This novel test protocol is an important step towards a practical task for comparative studies on judgement biases in animals. |
format | Online Article Text |
id | pubmed-5865189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58651892018-03-27 A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task Hintze, Sara Melotti, Luca Colosio, Simona Bailoo, Jeremy D. Boada-Saña, Maria Würbel, Hanno Murphy, Eimear Sci Rep Article Judgement bias tasks are promising tools to assess emotional valence in animals, however current designs are often time-consuming and lack aspects of validity. This study aimed to establish an improved design that addresses these issues and can be used across species. Horses, rats, and mice were trained on a spatial Go/No-go task where animals could initiate each trial. The location of an open goal-box, at either end of a row of five goal-boxes, signalled either reward (positive trial) or non-reward (negative trial). Animals first learned to approach the goal-box in positive trials (Go) and to re-initiate/not approach in negative trials (No-go). Animals were then tested for responses to ambiguous trials where goal-boxes at intermediate locations were opened. The Go:No-go response ratio was used as a measure of judgement bias. Most animals quickly learned the Go/No-go discrimination and performed trials at a high rate compared to previous studies. Subjects of all species reliably discriminated between reference cues and ambiguous cues, demonstrating a monotonic graded response across the different cue locations, with no evidence of learning about the outcome of ambiguous trials. This novel test protocol is an important step towards a practical task for comparative studies on judgement biases in animals. Nature Publishing Group UK 2018-03-23 /pmc/articles/PMC5865189/ /pubmed/29572529 http://dx.doi.org/10.1038/s41598-018-23459-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hintze, Sara Melotti, Luca Colosio, Simona Bailoo, Jeremy D. Boada-Saña, Maria Würbel, Hanno Murphy, Eimear A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title | A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title_full | A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title_fullStr | A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title_full_unstemmed | A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title_short | A cross-species judgement bias task: integrating active trial initiation into a spatial Go/No-go task |
title_sort | cross-species judgement bias task: integrating active trial initiation into a spatial go/no-go task |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865189/ https://www.ncbi.nlm.nih.gov/pubmed/29572529 http://dx.doi.org/10.1038/s41598-018-23459-3 |
work_keys_str_mv | AT hintzesara acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT melottiluca acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT colosiosimona acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT bailoojeremyd acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT boadasanamaria acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT wurbelhanno acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT murphyeimear acrossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT hintzesara crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT melottiluca crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT colosiosimona crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT bailoojeremyd crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT boadasanamaria crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT wurbelhanno crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask AT murphyeimear crossspeciesjudgementbiastaskintegratingactivetrialinitiationintoaspatialgonogotask |