Cargando…

Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome

Differentiation of hematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factor function can be the basis of (pre)malignancies such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Growth factor independence 1b (Gfi1b) is a r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thivakaran, Aniththa, Botezatu, Lacramioara, Hönes, Judith M., Schütte, Judith, Vassen, Lothar, Al-Matary, Yahya S., Patnana, Pradeep, Zeller, Amos, Heuser, Michael, Thol, Felicitas, Gabdoulline, Razif, Olberding, Nadine, Frank, Daria, Suslo, Marina, Köster, Renata, Lennartz, Klaus, Görgens, Andre, Giebel, Bernd, Opalka, Bertram, Dührsen, Ulrich, Khandanpour, Cyrus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865438/ https://www.ncbi.nlm.nih.gov/pubmed/29326122 http://dx.doi.org/10.3324/haematol.2017.167288

Ejemplares similares

Enforced GFI1 expression impedes human and murine leukemic cell growth
por: Hönes, Judith M., et al.
Publicado: (2017)

Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs
por: Xie, Xiaoqing, et al.
Publicado: (2023)

Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b
por: Vassen, Lothar, et al.
Publicado: (2005)

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome
por: Botezatu, Lacramioara, et al.
Publicado: (2016)

GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia
por: Liu, Longlong, et al.
Publicado: (2022)

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition
por: Vorwerk, Jan, et al.
Publicado: (2022)

Gfi1 as a regulator of p53 and a therapeutic target for ALL
por: Khandanpour, Cyrus, et al.
Publicado: (2013)

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic Implications
por: Möröy, Tarik, et al.
Publicado: (2019)

Curcumin as an Epigenetic Therapeutic Agent in Myelodysplastic Syndromes (MDS)
por: Xie, Xiaoqing, et al.
Publicado: (2021)

Newly diagnosed isolated myeloid sarcoma–paired NGS panel analysis of extramedullary tumor and bone marrow
por: Engel, Nils W., et al.
Publicado: (2020)

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
por: Beauchemin, Hugues, et al.
Publicado: (2017)

Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1
por: Schulz, Danae, et al.
Publicado: (2012)

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
por: Fraszczak, Jennifer, et al.
Publicado: (2018)

Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression
por: Vassen, Lothar, et al.
Publicado: (2014)

Risk of tumor lysis syndrome in patients with acute myeloid leukemia treated with venetoclax-containing regimens without dose ramp-up
por: Shahswar, Rabia, et al.
Publicado: (2020)

Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1
por: Fraszczak, Jennifer, et al.
Publicado: (2016)

Gfi1 and Gfi1b Repress Rag Transcription in Plasmacytoid Dendritic Cells In Vitro
por: Chow, Kwan T., et al.
Publicado: (2013)

High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia
por: Liu, Longlong, et al.
Publicado: (2022)

Prevalence of the GFI1-36N SNP in Multiple Myeloma Patients and Its Impact on the Prognosis
por: Khandanpour, Cyrus, et al.
Publicado: (2021)

Structural Variants as a Basis for Targeted Therapies in Hematological Malignancies
por: Schütte, Judith, et al.
Publicado: (2019)

CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo
por: Dampmann, Maria, et al.
Publicado: (2020)

Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment
por: Beauchemin, Hugues, et al.
Publicado: (2020)

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia
por: Sharma, Amit, et al.
Publicado: (2020)

Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation
por: Faleschini, Michela, et al.
Publicado: (2021)

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1
por: Vadnais, Charles, et al.
Publicado: (2018)

qPIPSA: Relating enzymatic kinetic parameters and interaction fields
por: Gabdoulline, Razif R, et al.
Publicado: (2007)

GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival
por: Petrusca, Daniela N., et al.
Publicado: (2022)

GFI Network Security and PCI Compliance Power Tools
por: Posey, Brien
Publicado: (2008)

Gfi1: A unique controller of T(reg) cells
por: Shi, Lewis Zhichang, et al.
Publicado: (2013)

Transcription Factor GFI1B in Health and Disease
por: Anguita, Eduardo, et al.
Publicado: (2017)

Targeted Inhibition of the NUP98-NSD1 Fusion Oncogene in Acute Myeloid Leukemia
por: Mohanty, Sagarajit, et al.
Publicado: (2020)

On the structure and dynamics of the complex of the nucleosome and the linker histone
por: Pachov, Georgi V., et al.
Publicado: (2011)

Synergistic activity of IDH1 inhibitor BAY1436032 with azacitidine in IDH1 mutant acute myeloid leukemia
por: Chaturvedi, Anuhar, et al.
Publicado: (2020)

MRD as Biomarker for Response to Donor Lymphocyte Infusion after Allogeneic Hematopoietic Cell Transplantation in Patients with AML
por: Teich, Katrin, et al.
Publicado: (2023)

Human yolk sac-like haematopoiesis generates RUNX1-, GFI1- and/or GFI1B-dependent blood and SOX17-positive endothelium
por: Bruveris, Freya F., et al.
Publicado: (2020)

Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis
por: Zhang, Yangyang, et al.
Publicado: (2019)

IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction—a retrospective propensity score analysis
por: Kattih, Badder, et al.
Publicado: (2020)

Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
por: Kloos, Arnold, et al.
Publicado: (2020)

Correction: Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia
por: Kloos, Arnold, et al.
Publicado: (2021)

P510: PREDICTORS OF RESPONSE AND OUTCOME IN PATIENTS WITH REFRACTORY/RELAPSED ACUTE MYELOID LEUKEMIA RECEIVING VENETOCLAX WITH NON-INTENSIVE CHEMOTHERAPY
por: Krüger, Katja, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2ku43hqjebv3vbh1akho1cd62s