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Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial

BACKGROUND: Dietary fish is a rich source of Omega-3 poly-unsaturated fatty acids (PUFAs). These compounds may have protective effect against cardiovascular events possibly by modifying lipid profiles. Consequently, fish oil supplements are produced commercially to complement low fish intake. It is...

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Autores principales: Zibaeenezhad, Mohammad Javad, Ghavipisheh, Maryam, Attar, Armin, Aslani, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865539/
https://www.ncbi.nlm.nih.gov/pubmed/29259181
http://dx.doi.org/10.1038/s41387-017-0007-8
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author Zibaeenezhad, Mohammad Javad
Ghavipisheh, Maryam
Attar, Armin
Aslani, Amir
author_facet Zibaeenezhad, Mohammad Javad
Ghavipisheh, Maryam
Attar, Armin
Aslani, Amir
author_sort Zibaeenezhad, Mohammad Javad
collection PubMed
description BACKGROUND: Dietary fish is a rich source of Omega-3 poly-unsaturated fatty acids (PUFAs). These compounds may have protective effect against cardiovascular events possibly by modifying lipid profiles. Consequently, fish oil supplements are produced commercially to complement low fish intake. It is not clear if both interventions have similar effects. The aim of this trial was to compare the anti-hyperlipidemic effect of omega3 fatty acid supplements with fresh fish. METHOD: A total of 106 patients with hyperlipidemia were randomized. One group received 2 g/day of omega-3 capsules for a period of 8 weeks and the other group received a mean of 250 g trout fish twice weekly (for dinner and lunch) for the same time period. The effects of these diets on the lipid profile after the intervention were compared between the two groups. RESULTS: Data from 48 patients in fish oil group and 47 patients from fish group was used for final analysis. In both groups, total cholesterol, non-HDL cholesterol, triglyceride (TG) levels, and Castelli I index (total cholesterol/HDL ratio) were reduced significantly following the treatment; however, dietary-fish intake had a more pronounced effect (−85.08 ± 74.82 vs. −30.75 ± 89.00, P < 0.001; 75.06 ± 35.43 vs. −16.93 ± 40.21, P < 0.001; −66.55 ± 30.79 vs. −12.7 ± 35.48, P = 0.003; and −0.77 ± 1.39 vs. −3.02 ± 1.85, P < 0.001; respectively). HDL level was increased in both groups with a higher effect in dietary fish group (4.47 ± 7.83 vs. 8.51 ± 8.79, P = 0.022). Atherogenic (Log [TG/HDL ratio]) and Castelli II (LDL/HDL ratio) indices did not change in fish oil group while were reduced significantly by fresh fish consumption (−0.04 ± 0.27 vs. −0.26 ± 0.17, P < 0.001; and 0.15 ± 0.7 vs. -1.32 ± 1.15, P < 0.001, respectively). LDL level was increased in the supplementation group, while it was significantly reduced in the dietary-fish group (+18.7 ± 24.97 vs. −22.75 ± 27.28, P < 0.001). CONCLUSION: Consumption of fresh fish seems to be superior in positively modifying the lipid profiles which may have important translations in the occurrence of cardiovascular events.
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spelling pubmed-58655392018-03-29 Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial Zibaeenezhad, Mohammad Javad Ghavipisheh, Maryam Attar, Armin Aslani, Amir Nutr Diabetes Article BACKGROUND: Dietary fish is a rich source of Omega-3 poly-unsaturated fatty acids (PUFAs). These compounds may have protective effect against cardiovascular events possibly by modifying lipid profiles. Consequently, fish oil supplements are produced commercially to complement low fish intake. It is not clear if both interventions have similar effects. The aim of this trial was to compare the anti-hyperlipidemic effect of omega3 fatty acid supplements with fresh fish. METHOD: A total of 106 patients with hyperlipidemia were randomized. One group received 2 g/day of omega-3 capsules for a period of 8 weeks and the other group received a mean of 250 g trout fish twice weekly (for dinner and lunch) for the same time period. The effects of these diets on the lipid profile after the intervention were compared between the two groups. RESULTS: Data from 48 patients in fish oil group and 47 patients from fish group was used for final analysis. In both groups, total cholesterol, non-HDL cholesterol, triglyceride (TG) levels, and Castelli I index (total cholesterol/HDL ratio) were reduced significantly following the treatment; however, dietary-fish intake had a more pronounced effect (−85.08 ± 74.82 vs. −30.75 ± 89.00, P < 0.001; 75.06 ± 35.43 vs. −16.93 ± 40.21, P < 0.001; −66.55 ± 30.79 vs. −12.7 ± 35.48, P = 0.003; and −0.77 ± 1.39 vs. −3.02 ± 1.85, P < 0.001; respectively). HDL level was increased in both groups with a higher effect in dietary fish group (4.47 ± 7.83 vs. 8.51 ± 8.79, P = 0.022). Atherogenic (Log [TG/HDL ratio]) and Castelli II (LDL/HDL ratio) indices did not change in fish oil group while were reduced significantly by fresh fish consumption (−0.04 ± 0.27 vs. −0.26 ± 0.17, P < 0.001; and 0.15 ± 0.7 vs. -1.32 ± 1.15, P < 0.001, respectively). LDL level was increased in the supplementation group, while it was significantly reduced in the dietary-fish group (+18.7 ± 24.97 vs. −22.75 ± 27.28, P < 0.001). CONCLUSION: Consumption of fresh fish seems to be superior in positively modifying the lipid profiles which may have important translations in the occurrence of cardiovascular events. Nature Publishing Group UK 2017-12-19 /pmc/articles/PMC5865539/ /pubmed/29259181 http://dx.doi.org/10.1038/s41387-017-0007-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zibaeenezhad, Mohammad Javad
Ghavipisheh, Maryam
Attar, Armin
Aslani, Amir
Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title_full Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title_fullStr Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title_full_unstemmed Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title_short Comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
title_sort comparison of the effect of omega-3 supplements and fresh fish on lipid profile: a randomized, open-labeled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865539/
https://www.ncbi.nlm.nih.gov/pubmed/29259181
http://dx.doi.org/10.1038/s41387-017-0007-8
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