Novel natural withanolides induce apoptosis and inhibit migration of neuroblastoma cells through down regulation of N-myc and suppression of Akt/mTOR/NF-κB activation

Despite recent advances in intensive chemotherapy treatments, long-term success is achieved in less than 30% of children with high-risk neuroblastoma (NB). Key regulatory pathways including the PI3K/Akt, mTOR and NF-κB are implicated in the pathogenesis of NB. Although drugs targeting these individu...

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Detalles Bibliográficos
Autores principales: Subramanian, Chitra, Grogan, Patrick T., Opipari, Valerie P., Timmermann, Barbara N., Cohen, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865686/
https://www.ncbi.nlm.nih.gov/pubmed/29581860
http://dx.doi.org/10.18632/oncotarget.24429

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