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Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker
Osteoprotegerin (OPG), a member of the tumour necrosis factor receptor (TNFR) superfamily of proteins known to be involved in a large number of biological systems, plays a pivotal role in bone remodelling. In addition to the roles of OPG in bone metabolism, it has been reported to be associated with...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865809/ https://www.ncbi.nlm.nih.gov/pubmed/28849089 http://dx.doi.org/10.3892/mmr.2017.7376 |
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author | Barbu, Carmen G. Arsene, Andreea L. Florea, Suzana Albu, Alice Sirbu, Anca Martin, Sorina Nicolae, Alina C. Burcea-Dragomiroiu, George T.A. Popa, Daniela E. Velescu, Bruno S. Dumitrescu, Ion B. Mitrea, Niculina Draganescu, Doina Lupuliasa, Dumitru Spandidos, Demetrios A. Tsatsakis, Aristides M. Dragoi, Cristina M. Fica, Simona |
author_facet | Barbu, Carmen G. Arsene, Andreea L. Florea, Suzana Albu, Alice Sirbu, Anca Martin, Sorina Nicolae, Alina C. Burcea-Dragomiroiu, George T.A. Popa, Daniela E. Velescu, Bruno S. Dumitrescu, Ion B. Mitrea, Niculina Draganescu, Doina Lupuliasa, Dumitru Spandidos, Demetrios A. Tsatsakis, Aristides M. Dragoi, Cristina M. Fica, Simona |
author_sort | Barbu, Carmen G. |
collection | PubMed |
description | Osteoprotegerin (OPG), a member of the tumour necrosis factor receptor (TNFR) superfamily of proteins known to be involved in a large number of biological systems, plays a pivotal role in bone remodelling. In addition to the roles of OPG in bone metabolism, it has been reported to be associated with a high cardiovascular risk in patients with metabolic syndrome. In most cases, the exact functions of OPG remain to be established; however, the widespread expression of OPG suggests that this molecule may have multiple biological activities, mainly in the cardiometabolic environment. The aim of this study was to evaluate the value of OPG as a predictive marker for cardiovascular and metabolic risk in osteoporotic patients. The study group comprised patients with osteoporosis, in order to evaluate the association between OPG serum levels and cardiovascular pathology. Our results revealed significant correlations between classical biochemical bone and metabolic parameters, such as osteocalcin and parathyroid hormone with lipid and glucose biomarkers, sustaining the crosstalk between calcium and bone parameters and cardiovascular risk. The OPG serum level proved to have a significant and independent predictive value for metabolic syndrome (MetS) as a cardiovascular risk standard in osteoporotic patients. The OPG serum levels were increased in patients with MetS as a protective response against the atherosclerotic lesions. The serum levels of 25-hydroxy vitamin D had significant and independent predictive value for cardiovascular and metabolic risk in our subjects, sustaining the active role of vitamin D beyond the area of bone metabolism. |
format | Online Article Text |
id | pubmed-5865809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-58658092018-03-27 Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker Barbu, Carmen G. Arsene, Andreea L. Florea, Suzana Albu, Alice Sirbu, Anca Martin, Sorina Nicolae, Alina C. Burcea-Dragomiroiu, George T.A. Popa, Daniela E. Velescu, Bruno S. Dumitrescu, Ion B. Mitrea, Niculina Draganescu, Doina Lupuliasa, Dumitru Spandidos, Demetrios A. Tsatsakis, Aristides M. Dragoi, Cristina M. Fica, Simona Mol Med Rep Articles Osteoprotegerin (OPG), a member of the tumour necrosis factor receptor (TNFR) superfamily of proteins known to be involved in a large number of biological systems, plays a pivotal role in bone remodelling. In addition to the roles of OPG in bone metabolism, it has been reported to be associated with a high cardiovascular risk in patients with metabolic syndrome. In most cases, the exact functions of OPG remain to be established; however, the widespread expression of OPG suggests that this molecule may have multiple biological activities, mainly in the cardiometabolic environment. The aim of this study was to evaluate the value of OPG as a predictive marker for cardiovascular and metabolic risk in osteoporotic patients. The study group comprised patients with osteoporosis, in order to evaluate the association between OPG serum levels and cardiovascular pathology. Our results revealed significant correlations between classical biochemical bone and metabolic parameters, such as osteocalcin and parathyroid hormone with lipid and glucose biomarkers, sustaining the crosstalk between calcium and bone parameters and cardiovascular risk. The OPG serum level proved to have a significant and independent predictive value for metabolic syndrome (MetS) as a cardiovascular risk standard in osteoporotic patients. The OPG serum levels were increased in patients with MetS as a protective response against the atherosclerotic lesions. The serum levels of 25-hydroxy vitamin D had significant and independent predictive value for cardiovascular and metabolic risk in our subjects, sustaining the active role of vitamin D beyond the area of bone metabolism. D.A. Spandidos 2017-11 2017-08-28 /pmc/articles/PMC5865809/ /pubmed/28849089 http://dx.doi.org/10.3892/mmr.2017.7376 Text en Copyright: © Barbu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Barbu, Carmen G. Arsene, Andreea L. Florea, Suzana Albu, Alice Sirbu, Anca Martin, Sorina Nicolae, Alina C. Burcea-Dragomiroiu, George T.A. Popa, Daniela E. Velescu, Bruno S. Dumitrescu, Ion B. Mitrea, Niculina Draganescu, Doina Lupuliasa, Dumitru Spandidos, Demetrios A. Tsatsakis, Aristides M. Dragoi, Cristina M. Fica, Simona Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title | Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title_full | Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title_fullStr | Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title_full_unstemmed | Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title_short | Cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
title_sort | cardiovascular risk assessment in osteoporotic patients using osteoprotegerin as a reliable predictive biochemical marker |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865809/ https://www.ncbi.nlm.nih.gov/pubmed/28849089 http://dx.doi.org/10.3892/mmr.2017.7376 |
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