Cargando…

Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let-7c targeting of antiapoptotic BCL2L1

Colorectal cancer (CRC) remains a primary contributor to cancer-associated mortality. The Lin28/let-7 axis has previously been verified to participate in numerous pathophysiological processes involved in CRC. However, the potential roles and underlying mechanisms of this axis in apoptosis during CRC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Haogang, Zong, Yaguang, Qiu, Gongcai, Jia, Ruichun, Xu, Xunzheng, Wang, Fujing, Wu, Dequan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865979/ https://www.ncbi.nlm.nih.gov/pubmed/29393430 http://dx.doi.org/10.3892/mmr.2018.8483

Ejemplares similares

Catalpol protects mice against Lipopolysaccharide/D-galactosamine-induced acute liver injury through inhibiting inflammatory and oxidative response
por: Zhang, Haogang, et al.
Publicado: (2017)

The LIN28/let-7 Pathway in Cancer
por: Balzeau, Julien, et al.
Publicado: (2017)

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2019)

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
por: Wang, Tianzhen, et al.
Publicado: (2015)

The Lin28/let-7 axis is critical for myelination in the peripheral nervous system
por: Gökbuget, Deniz, et al.
Publicado: (2015)

LIN28B and Let-7 in Diffuse Midline Glioma: A Review
por: Knowles, Truman, et al.
Publicado: (2023)

Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development
por: Ali, Asghar, et al.
Publicado: (2022)

The Lin28 cold-shock domain remodels pre-let-7 microRNA
por: Mayr, Florian, et al.
Publicado: (2012)

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
por: Madison, Blair B., et al.
Publicado: (2013)

The Lin28/Let-7 System in Early Human Embryonic Tissue and Ectopic Pregnancy
por: Lozoya, Teresa, et al.
Publicado: (2014)

Bistable Switch in let-7 miRNA Biogenesis Pathway Involving Lin28
por: Shi, Fei, et al.
Publicado: (2014)

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis
por: Bhattacharya, Debadrita, et al.
Publicado: (2018)

The Role of LIN28-let-7-ARID3B Pathway in Placental Development
por: Ali, Asghar, et al.
Publicado: (2020)

Author Correction: Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
por: Yermalovich, Alena V., et al.
Publicado: (2020)

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28
por: Wang, Longfei, et al.
Publicado: (2018)

A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7
por: Yu, Chunxiao, et al.
Publicado: (2020)

Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
por: Faehnle, Christopher R., et al.
Publicado: (2014)

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway
por: Pérez, Laura M., et al.
Publicado: (2013)

The LIN28B/let-7 axis is a novel therapeutic pathway in Multiple Myeloma
por: Manier, Salomon, et al.
Publicado: (2016)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Resistin Induces LIN28A-Mediated Let-7a Repression in Breast Cancer Cells Leading to IL-6 and STAT3 Upregulation
por: Deshmukh, Sachin Kumar, et al.
Publicado: (2021)

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in embryonic stem cells
por: Hagan, John P., et al.
Publicado: (2009)

Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors
por: Desjardins, Alexandre, et al.
Publicado: (2014)

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma
por: Lozier, Ann M., et al.
Publicado: (2014)

A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B
por: Suzuki, Hiroshi I, et al.
Publicado: (2015)

Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
por: Rowe, R. Grant, et al.
Publicado: (2016)

Crystal structure of the Lin28-interacting module of human terminal uridylyltransferase that regulates let-7 expression
por: Yamashita, Seisuke, et al.
Publicado: (2019)

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing
por: Lightfoot, Helen L., et al.
Publicado: (2016)

Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7
por: Borgelt, Lydia, et al.
Publicado: (2021)

miR-326 Targets Antiapoptotic Bcl-xL and Mediates Apoptosis in Human Platelets
por: Yu, Shifang, et al.
Publicado: (2015)

Comparison of the expression and function of Lin28A and Lin28B in colon cancer
por: Wang, Tianzhen, et al.
Publicado: (2016)

Mutual connected IL-6, EGFR and LIN28/Let7-related mechanisms modulate PD-L1 and IGF upregulation in HNSCC using immunotherapy
por: Li, Junjun, et al.
Publicado: (2023)

LIN-10 can promote LET-23 EGFR signaling and trafficking independently of LIN-2 and LIN-7
por: Gauthier, Kimberley D., et al.
Publicado: (2021)

Correction: Comparison of the expression and function of Lin28A and Lin28B in colon cancer
por: Wang, Tianzhen, et al.
Publicado: (2021)

Importance of the NCp7-like domain in the recognition of pre-let-7g by the pluripotency factor Lin28
por: Desjardins, Alexandre, et al.
Publicado: (2012)

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans
por: Van Wynsberghe, Priscilla M., et al.
Publicado: (2011)

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
por: Chang, Hao-Ming, et al.
Publicado: (2013)

Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner
por: Ma, Lihong, et al.
Publicado: (2018)

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling
por: Yin, Jinlong, et al.
Publicado: (2016)

SUMOylation modulates the LIN28A‐let‐7 signaling pathway in response to cellular stresses in cancer cells
por: Dou, Jinzhuo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qqsn5ls3qo0kuuft2anp4mgimn