Cargando…

Ouabain suppresses the growth and migration abilities of glioma U-87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF-1α

Mostrar otras versiones (1)

Glioma is one of the most malignant forms of brain tumor, and has been of persistent concern due to its high recurrence and mortality rates, and limited therapeutic options. As a cardiac glycoside, ouabain has widespread applications in congestive heart diseases due to its positive cardiac inotropic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xiao-Sa, Xu, Zhong-Wei, Yi, Tai-Long, Xu, Rui-Cheng, Li, Jie, Zhang, Wen-Bin, Zhang, Sai, Sun, Hong-Tao, Yu, Ze-Qi, Xu, Hao-Xiang, Tu, Yue, Cheng, Shi-Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865999/ https://www.ncbi.nlm.nih.gov/pubmed/29436645 http://dx.doi.org/10.3892/mmr.2018.8587

Ejemplares similares

Ouabain suppresses the growth and migration abilities of glioma U-87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF-1α
por: Yang, Xiao-Sa, et al.
Publicado: (2021)

IDH1-R132H mutation radiosensitizes U87MG glioma cells via epigenetic downregulation of TIGAR
por: Yin, Narui, et al.
Publicado: (2020)

SIL1 functions as an oncogene in glioma by AKT/mTOR signaling pathway
por: Xu, Hao, et al.
Publicado: (2018)

RNAi for contactin 2 inhibits proliferation of U87-glioma stem cells by downregulating AICD, EGFR, and HES1
por: Guo, Yang, et al.
Publicado: (2017)

Solid Lipid Nanoparticles of Albendazole for Enhancing Cellular Uptake and Cytotoxicity against U-87 MG Glioma Cell Lines
por: Marslin, Gregory, et al.
Publicado: (2017)

Suppressing H19 Modulates Tumorigenicity and Stemness in U251 and U87MG Glioma Cells
por: Li, Weiguo, et al.
Publicado: (2016)

Epigenetic downregulation of STAT6 increases HIF-1α expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells
por: Park, Soo Jung, et al.
Publicado: (2019)

HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway
por: Xu, Wen-Ning, et al.
Publicado: (2020)

The effect of downregulation of Stathmin gene on biological behaviors of U373 and U87-MG glioblastoma cells
por: Liu, Ping, et al.
Publicado: (2018)

Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway
por: Li, Songyuan, et al.
Publicado: (2016)

Oligomer procyanidins (F2) repress HIF-1α expression in human U87 glioma cells by inhibiting the EGFR/ AKT/mTOR and MAPK/ERK1/2 signaling pathways in vitro and in vivo
por: Zheng, Hong-Li, et al.
Publicado: (2017)

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1α axis inhibition
por: Nguyen, Aurélia, et al.
Publicado: (2017)

Ouabaïne
Publicado: (1891)

Xihuang Pill Induces Apoptosis of Human Glioblastoma U-87 MG Cells via Targeting ROS-Mediated Akt/mTOR/FOXO1 Pathway
por: Shao, Meng, et al.
Publicado: (2018)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

HIF is not essential for suppression of experimental tumor growth by mTOR inhibition
por: Knaup, Karl X., et al.
Publicado: (2017)

HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia
por: Shao, Chao, et al.
Publicado: (2019)

Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth
por: Guo, Yangyang, et al.
Publicado: (2020)

LOXL3 Silencing Affected Cell Adhesion and Invasion in U87MG Glioma Cells
por: Laurentino, Talita de S., et al.
Publicado: (2021)

Hedyotis diffusa Willd. Suppresses Hepatocellular Carcinoma via Downregulating AKT/mTOR Pathways
por: Huang, Lingli, et al.
Publicado: (2021)

Canagliflozin attenuates lipotoxicity in cardiomyocytes and protects diabetic mouse hearts by inhibiting the mTOR/HIF-1α pathway
por: Sun, Pengbo, et al.
Publicado: (2021)

Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway
por: Ling, Bai, et al.
Publicado: (2023)

Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling
por: Okoye, Isobel, et al.
Publicado: (2017)

Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1α/VEGF activation in retina endothelial cells
por: Wang, Ning, et al.
Publicado: (2021)

GSK343 induces autophagy and downregulates the AKT/mTOR signaling pathway in pancreatic cancer cells
por: Xu, Hao, et al.
Publicado: (2019)

Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3
por: Du, Jie, et al.
Publicado: (2021)

The Na+/K+ ATPase Inhibitor Ouabain Attenuates Stemness and Chemoresistance of Osteosarcoma Cells
por: Guo, Weixiong, et al.
Publicado: (2019)

Hirudin inhibits glioma growth through mTOR‐regulated autophagy
por: Ma, Ying, et al.
Publicado: (2023)

Angiogenin Promotes U87MG Cell Proliferation by Activating NF-κB Signaling Pathway and Downregulating Its Binding Partner FHL3
por: Xia, Wenrong, et al.
Publicado: (2015)

Inhibition of HIF1A-AS1 promoted starvation-induced hepatocellular carcinoma cell apoptosis by reducing HIF-1α/mTOR-mediated autophagy
por: Hong, Fenfen, et al.
Publicado: (2020)

Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells
por: Bernhart, Eva, et al.
Publicado: (2015)

Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells
por: Sukumari-Ramesh, Sangeetha, et al.
Publicado: (2015)

MicroRNA-200c affects bladder cancer angiogenesis by regulating the Akt2/mTOR/HIF-1 axis
por: Wu, Shui-Qing, et al.
Publicado: (2019)

Proteomic Analysis between U87MG and U343MG-A Cell Lines: Searching for Candidate Proteins for Glioma Invasion
por: Pei, Jian, et al.
Publicado: (2014)

Downregulation of BZW2 inhibits osteosarcoma cell growth by inactivating the Akt/mTOR signaling pathway
por: Cheng, Dong-Dong, et al.
Publicado: (2017)

Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis☆
por: Xie, Yunliang, et al.
Publicado: (2012)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways
por: Shen, Yehua, et al.
Publicado: (2019)

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
por: Weng, Mei-lin, et al.
Publicado: (2020)

Resveratrol represses YKL-40 expression in human glioma U87 cells
por: Zhang, Wei, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ine65ui9i537am81rqon743pej