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Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive wei...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866193/ https://www.ncbi.nlm.nih.gov/pubmed/29476613 http://dx.doi.org/10.1002/oby.22129 |
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author | Chondronikola, Maria Magkos, Faidon Yoshino, Jun Okunade, Adewole L. Patterson, Bruce W. Muehlbauer, Michael J. Newgard, Christopher B. Klein, Samuel |
author_facet | Chondronikola, Maria Magkos, Faidon Yoshino, Jun Okunade, Adewole L. Patterson, Bruce W. Muehlbauer, Michael J. Newgard, Christopher B. Klein, Samuel |
author_sort | Chondronikola, Maria |
collection | PubMed |
description | OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI=37.9±4.3 kg/m(2)) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-(2)H(2)]glucose tracer infusion was used to assess glucose kinetics. RESULTS: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r=0.532, p=0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r=−0.361, p=0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r=0.654, p=0.002) and the increase in insulin sensitivity (r=−0.595, p=0.007). CONCLUSION: This study demonstrates the inter-relationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance. |
format | Online Article Text |
id | pubmed-5866193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-58661932018-08-24 Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial Chondronikola, Maria Magkos, Faidon Yoshino, Jun Okunade, Adewole L. Patterson, Bruce W. Muehlbauer, Michael J. Newgard, Christopher B. Klein, Samuel Obesity (Silver Spring) Article OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI=37.9±4.3 kg/m(2)) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-(2)H(2)]glucose tracer infusion was used to assess glucose kinetics. RESULTS: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r=0.532, p=0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r=−0.361, p=0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r=0.654, p=0.002) and the increase in insulin sensitivity (r=−0.595, p=0.007). CONCLUSION: This study demonstrates the inter-relationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance. 2018-02-24 2018-04 /pmc/articles/PMC5866193/ /pubmed/29476613 http://dx.doi.org/10.1002/oby.22129 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Chondronikola, Maria Magkos, Faidon Yoshino, Jun Okunade, Adewole L. Patterson, Bruce W. Muehlbauer, Michael J. Newgard, Christopher B. Klein, Samuel Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title | Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title_full | Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title_fullStr | Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title_full_unstemmed | Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title_short | Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial |
title_sort | effect of progressive weight loss on lactate metabolism: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866193/ https://www.ncbi.nlm.nih.gov/pubmed/29476613 http://dx.doi.org/10.1002/oby.22129 |
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