Cargando…

Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial

OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive wei...

Descripción completa

Detalles Bibliográficos
Autores principales: Chondronikola, Maria, Magkos, Faidon, Yoshino, Jun, Okunade, Adewole L., Patterson, Bruce W., Muehlbauer, Michael J., Newgard, Christopher B., Klein, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866193/
https://www.ncbi.nlm.nih.gov/pubmed/29476613
http://dx.doi.org/10.1002/oby.22129
_version_ 1783308811552948224
author Chondronikola, Maria
Magkos, Faidon
Yoshino, Jun
Okunade, Adewole L.
Patterson, Bruce W.
Muehlbauer, Michael J.
Newgard, Christopher B.
Klein, Samuel
author_facet Chondronikola, Maria
Magkos, Faidon
Yoshino, Jun
Okunade, Adewole L.
Patterson, Bruce W.
Muehlbauer, Michael J.
Newgard, Christopher B.
Klein, Samuel
author_sort Chondronikola, Maria
collection PubMed
description OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI=37.9±4.3 kg/m(2)) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-(2)H(2)]glucose tracer infusion was used to assess glucose kinetics. RESULTS: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r=0.532, p=0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r=−0.361, p=0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r=0.654, p=0.002) and the increase in insulin sensitivity (r=−0.595, p=0.007). CONCLUSION: This study demonstrates the inter-relationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance.
format Online
Article
Text
id pubmed-5866193
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-58661932018-08-24 Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial Chondronikola, Maria Magkos, Faidon Yoshino, Jun Okunade, Adewole L. Patterson, Bruce W. Muehlbauer, Michael J. Newgard, Christopher B. Klein, Samuel Obesity (Silver Spring) Article OBJECTIVE: Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss. METHODS: Forty people with obesity (BMI=37.9±4.3 kg/m(2)) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-(2)H(2)]glucose tracer infusion was used to assess glucose kinetics. RESULTS: At baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r=0.532, p=0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r=−0.361, p=0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r=0.654, p=0.002) and the increase in insulin sensitivity (r=−0.595, p=0.007). CONCLUSION: This study demonstrates the inter-relationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance. 2018-02-24 2018-04 /pmc/articles/PMC5866193/ /pubmed/29476613 http://dx.doi.org/10.1002/oby.22129 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chondronikola, Maria
Magkos, Faidon
Yoshino, Jun
Okunade, Adewole L.
Patterson, Bruce W.
Muehlbauer, Michael J.
Newgard, Christopher B.
Klein, Samuel
Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title_full Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title_fullStr Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title_full_unstemmed Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title_short Effect of Progressive Weight Loss on Lactate Metabolism: a Randomized Controlled Trial
title_sort effect of progressive weight loss on lactate metabolism: a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866193/
https://www.ncbi.nlm.nih.gov/pubmed/29476613
http://dx.doi.org/10.1002/oby.22129
work_keys_str_mv AT chondronikolamaria effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT magkosfaidon effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT yoshinojun effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT okunadeadewolel effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT pattersonbrucew effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT muehlbauermichaelj effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT newgardchristopherb effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial
AT kleinsamuel effectofprogressiveweightlossonlactatemetabolismarandomizedcontrolledtrial