Multifaceted Roles of Connexin 43 in Stem Cell Niches

PURPOSE OF REVIEW: Considerable progress has been made in the field of stem cell research; nonetheless, the use of stem cells for regenerative medicine therapies, for either endogenous tissue repair or cellular grafts post injury, remains a challenge. To better understand how to maintain stem cell p...

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Detalles Bibliográficos
Autores principales: Genet, Nafiisha, Bhatt, Neha, Bourdieu, Antonin, Hirschi, Karen K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Stem Cell Switches and Regulators (KK Hirschi, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866259/
https://www.ncbi.nlm.nih.gov/pubmed/29600160
http://dx.doi.org/10.1007/s40778-018-0110-3
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author Genet, Nafiisha
Bhatt, Neha
Bourdieu, Antonin
Hirschi, Karen K.
author_facet Genet, Nafiisha
Bhatt, Neha
Bourdieu, Antonin
Hirschi, Karen K.
author_sort Genet, Nafiisha
collection PubMed
description PURPOSE OF REVIEW: Considerable progress has been made in the field of stem cell research; nonetheless, the use of stem cells for regenerative medicine therapies, for either endogenous tissue repair or cellular grafts post injury, remains a challenge. To better understand how to maintain stem cell potential in vivo and promote differentiation ex vivo, it is fundamentally important to elucidate the interactions between stem cells and their surrounding partners within their distinct niches. RECENT FINDINGS: Among the vast array of proteins depicted as mediators for cell-to-cell interactions, connexin-comprised gap junctions play pivotal roles in the regulation of stem cell fate both in vivo and in vitro. SUMMARY: This review summarizes and illustrates the current knowledge regarding the multifaceted roles of Cx43, specifically, in various stem cell niches.
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spelling pubmed-58662592018-03-27 Multifaceted Roles of Connexin 43 in Stem Cell Niches Genet, Nafiisha Bhatt, Neha Bourdieu, Antonin Hirschi, Karen K. Curr Stem Cell Rep Stem Cell Switches and Regulators (KK Hirschi, Section Editor) PURPOSE OF REVIEW: Considerable progress has been made in the field of stem cell research; nonetheless, the use of stem cells for regenerative medicine therapies, for either endogenous tissue repair or cellular grafts post injury, remains a challenge. To better understand how to maintain stem cell potential in vivo and promote differentiation ex vivo, it is fundamentally important to elucidate the interactions between stem cells and their surrounding partners within their distinct niches. RECENT FINDINGS: Among the vast array of proteins depicted as mediators for cell-to-cell interactions, connexin-comprised gap junctions play pivotal roles in the regulation of stem cell fate both in vivo and in vitro. SUMMARY: This review summarizes and illustrates the current knowledge regarding the multifaceted roles of Cx43, specifically, in various stem cell niches. Springer International Publishing 2018-02-15 2018 /pmc/articles/PMC5866259/ /pubmed/29600160 http://dx.doi.org/10.1007/s40778-018-0110-3 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Stem Cell Switches and Regulators (KK Hirschi, Section Editor)
Genet, Nafiisha
Bhatt, Neha
Bourdieu, Antonin
Hirschi, Karen K.
Multifaceted Roles of Connexin 43 in Stem Cell Niches
title Multifaceted Roles of Connexin 43 in Stem Cell Niches
title_full Multifaceted Roles of Connexin 43 in Stem Cell Niches
title_fullStr Multifaceted Roles of Connexin 43 in Stem Cell Niches
title_full_unstemmed Multifaceted Roles of Connexin 43 in Stem Cell Niches
title_short Multifaceted Roles of Connexin 43 in Stem Cell Niches
title_sort multifaceted roles of connexin 43 in stem cell niches
topic Stem Cell Switches and Regulators (KK Hirschi, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866259/
https://www.ncbi.nlm.nih.gov/pubmed/29600160
http://dx.doi.org/10.1007/s40778-018-0110-3
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